Sintbad antibody | AB01/2C8
Mouse anti Human Sintbad
- Product Type
- Monoclonal Antibody
- Clone
- AB01/2C8
- Isotype
- IgG1
- Specificity
- Sintbad
Antibody Quality and Performance Guarantee
| Mouse anti Human SINTBAD antibody recognizes the protein SINTBAD, otherwise known as TANK-binding kinase 1-bindng protein 1 or TBK1-binding protein 1. SINTBAD acts as an adaptor protein and plays a role in antiviral innate responses by essentially binding to TBK1 and IKBKE (Ryzhakov and Randow, 2007). Interaction of these kinases induces phosphorylation and following activation of IRF-3 transcription factor thus leading to gene regulation for immune responses (Fitzgerald et al. 2003). There is evidence that show IKBKE and TBK1 are crucial oncogenes for activation of a number of signalling pathways in numerous tumours (Wang et al. 2019). In addition, SINTBAD protein is involved in the facilitation autophagy-initiating kinase ULK1 to control IL-15-induced autophagy in natural killer T cells (Zhu et al. 2018). Mouse anti Human SINTBAD antibody detects a band of 80 kDa. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- E. coli-derived recombinant protein, aa 1-279 of human TBKBP1
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Mouse anti Human SINTBAD antibody detects a band of 80 kDa in HEK293 cell lysates
- UniProt
- A7MCY6
- Entrez Gene
- TBKBP1
- GO Terms
- GO:0045087 innate immune response
MCA6410GA
100007434
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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