Serum Amyloid A antibody | SAA19

Mouse anti Human serum amyloid A, clone SAA19 recognizes the human serum amyloid A (SAA) protein, an acute phase protein belonging to the SAA family which is secreted into the plasma by the liver following injury or infection.

SAA is a widely used marker of inflamation as elevated levels of SAA may be detected in the blood of the individual following infection or tissue trauma.

Serum amyloid A is highly conserved between species with human SAA being similar in structure to SAA in other species. Studies have been undertaken that demonstrate monoclonal antibodies raised against human SAA can be used to develop assays for measurement of SAA in domestic animals (Christensen, M, et al.).

In addition to human SAA, clone SAA19 recognises canine, equine and feline SAA. Structurally canine, feline and equine SAA differ from human SAA in that they contain an 8 aa insert in the central region of the sequence, human SSA being 104 aa, equine SAA 110 aa, while canine and feline SAA are 111 aa.

Clone SAA19 may be use as a capture reagent along with clone VSA34 (MCA6031GA) as the detection reagent in the development of immunoassays to detect SAA in dogs, cats and horses along with recombinant SAA (for canine, product code PDP006, for feline, product code PFP003 and for equine, product code PEP006) as standards.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
ELISA
Western Blotting

ELISA

This product may be used in a direct ELISA or as a capture reagent in a sandwich ELISA, together with MCA6031GA, as the detection reagent.