Parkin antibody | 1H4
Mouse anti Human Parkin:Preservative Free
- Product Type
- Monoclonal Antibody
- Clone
- 1H4
- Isotype
- IgG3
- Specificity
- Parkin
Mouse anti Human Parkin antibody, clone 1H4 recognizes human E3 ubiquitin-protein ligase parkin, also known as Parkin or Parkinson juvenile disease protein 2. Parkin is a 465 amino acid ~ 50 kDa enzymatic component of a multiprotein E3 ubiquitin ligase complex. Mutations in the PARK2 gene has been noted to affect susceptibility to Parkinson's disease (PARK) and development of Parkinson disease 2, also known as autosomal recessive juvenile Parkinsonism (PARK2) which differs from classical Parkinson disease by early DOPA-induced dyskinesia, diurnal fluctuation of the symptoms, sleep benefit, dystonia and hyper-reflexia (Kitada et al. 1998). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Immunogen
- Recombinant protein corresponding to aa 288-388 of human PARK2
- Approx. Protein Concentrations
- Ig concentration 0.5 mg/ml
- Fusion Partners
- Spleen cells from Balb/c mice were fused with cells from the Sp2/0 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunofluorescence | 0.1 | 10 ug/ml | |
Western Blotting | 0.1 | 10 ug/ml |
References for Parkin antibody
-
Brody, K. M. et al (2008) Regional and cellular localisation of Parkin co-regulated gene in developing and adult mouse brain.
Brain Res. 1201: 177-86. -
Scuderi, S. et al. (2014) Alternative splicing generates different parkin protein isoforms: evidences in human, rat, and mouse brain.
Biomed Res Int. 2014:690796.
- RRID
- AB_2159924
- UniProt
- O60260
- Entrez Gene
- PARK2
MCA3315Z
166793 180115If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
View all Anti-Human ProductsAlways be the first to know.
When we launch new products and resources to help you achieve more in the lab.
Yes, sign me up