NCOR1 antibody | J02/11D2-8
Mouse anti Human NCOR1
- Product Type
- Monoclonal Antibody
- Clone
- J02/11D2-8
- Isotype
- IgG1
- Specificity
- NCOR1
Antibody Quality and Performance Guarantee
| Mouse anti human NCOR1 antibody, clone J02/11D2-8 recognizes nuclear receptor co-repressor 1 protein, also known as NCOR1 or KIAA1047. NCOR1 is a tumor suppressor gene, as when levels of this are reduced, there is an increase in tumor proliferation (Noblejas-Lopez et al. 2018). Mutations and deletions have been seen in the NCOR1 gene in colorectal and bladder cancer. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- E. coli-derived recombinant protein, aa 1-292 of human NCOR1.
- Approx. Protein Concentrations
- IgG concentration 1,0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/2,000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Mouse anti human NCOR1 detects a band of approximately 286 kDa in Jurkat cell lysates.
- UniProt
- O75376
- Entrez Gene
- NCOR1
- GO Terms
- GO:0003714 transcription corepressor activity
- GO:0005876 spindle microtubule
- GO:0006366 transcription from RNA polymerase II promoter
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010843 promoter binding
- GO:0016568 chromatin modification
- GO:0017053 transcriptional repressor complex
- GO:0042826 histone deacetylase binding
- GO:0044255 cellular lipid metabolic process
- View More GO Terms
- GO:0046329 negative regulation of JNK cascade
- GO:0051225 spindle assembly
- GO:0072362 regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter
- GO:0072368 regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter
- GO:2000191 regulation of fatty acid transport
MCA6429GA
100007869
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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