Mucin 5AC antibody | 1-13M1
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Mouse anti Human Mucin 5AC antibody, clone 1-13M1 recognizes the peptide core of gastric mucin, also knowen as Mucin-5AC, Lewis B blood group antigen, Major airway glycoprotein or Tracheobronchial mucin.
Mucins are high molecular weight glycoproteins found predominantly in the secretions of mucus membranes, protecting them from infection or chemical damage. Gastric Mucin 5AC antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. Resurgence of gastric mucin during colonic carcinogenesis is suggestive of either re-expression of the peptide core of gastric mucin in the adult colon or due to changes in the glycosylation pattern of mucin, which expose the hidden Mucin 5AC antigen. Mouse anti Human Mucin 5AC antibody, clone 1-13M1 has not been cross-adsorbed and may react with related peptides from other species.
Mucins are high molecular weight glycoproteins found predominantly in the secretions of mucus membranes, protecting them from infection or chemical damage. Gastric Mucin 5AC antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. Resurgence of gastric mucin during colonic carcinogenesis is suggestive of either re-expression of the peptide core of gastric mucin in the adult colon or due to changes in the glycosylation pattern of mucin, which expose the hidden Mucin 5AC antigen. Mouse anti Human Mucin 5AC antibody, clone 1-13M1 has not been cross-adsorbed and may react with related peptides from other species.
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.02% Sodium Azide (NaN3) - Immunogen
- A BALB/c mouse was immunized with mucin isolated from an ovarian cyst fluid (pure endocervical type according to the Fenoglio's classification).
- Approx. Protein Concentrations
- IgG concentration 0.1 mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Shelf Life
- Please see label for expiry date.
More Information
- UniProt
- P98088 Related reagents
- Entrez Gene
- MUC5AC Related reagents
- Regulatory
- For research purposes only
Applications of Mucin 5AC antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | |||
| Immunohistology - Frozen | |||
| Immunohistology - Paraffin 1 | |||
| Western Blotting 2 |
- 1This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.
- 2Clone 1-13M1 recognizes Mucin 5AC under non-reducing conditions.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Product Specific References
References for Mucin 5AC antibody
-
Fang, C. et al. (2012) Resistin-like molecule-β is a human airway remodelling mediator.
Eur Respir J. 39 (2): 458-66. -
Ramaglia L et al. (2015) Differentiation, apoptosis, and GM-CSF receptor expression of human gingival fibroblasts on a titanium surface treated by a dual acid-etched procedure.
Clin Oral Investig. Apr 17. [Epub ahead of print]
