IRS2 antibody | G01-8F7
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WB ResetMouse anti Human IRS2
- Product Type
- Monoclonal Antibody
- Clone
- G01-8F7
- Isotype
- IgG1
- Specificity
- IRS2
Antibody Quality and Performance Guarantee
MCA6414GA
| Mouse anti human IRS2 antibody, clone G01-8F7 recognizes insulin receptor substrate 2. IRS2 is a cytoplasmic signaling molecule. IRS2 along with IRS1, is a key target of the insulin receptor tyrosine kinase. Serine/threonine phosphorylation of IRS2 has been shown to regulate insulin sensitivity, suggesting that it is required for hormonal control of metabolism (Copps and White, 2012). Reduced expression of IRS2 has been shown to result in type 2 diabetes and reduced brain mass in mice (Lin et al. 2004, Schubert et al. 2003) |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- E. coli-derived recombinant protein, aa 1035-1338 of human IRS2
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/500 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Mouse anti Human IRS2 antibody detects a band of 180 kDa in THP-1 cell lysates
- UniProt
- Q9Y4H2
- Entrez Gene
- IRS2
- GO Terms
- GO:0005886 plasma membrane
- GO:0002903 negative regulation of B cell apoptosis
- GO:0005829 cytosol
- GO:0004871 signal transducer activity
- GO:0006006 glucose metabolic process
- GO:0008286 insulin receptor signaling pathway
- GO:0008543 fibroblast growth factor receptor signaling pathway
- GO:0009749 response to glucose stimulus
- GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport
- View More GO Terms
- GO:0046326 positive regulation of glucose import
- GO:0048015 phosphatidylinositol-mediated signaling
- GO:0030890 positive regulation of B cell proliferation
- GO:0032000 positive regulation of fatty acid beta-oxidation
- GO:0032024 positive regulation of insulin secretion
- GO:0033673 negative regulation of kinase activity
- GO:0045725 positive regulation of glycogen biosynthetic process
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0055088 lipid homeostasis
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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