Integrin Alpha 7 antibody | 8G2
Mouse anti Human Integrin Alpha 7:Preservative Free
- Product Type
- Monoclonal Antibody
- Clone
- 8G2
- Isotype
- IgG2a
- Specificity
- Integrin Alpha 7
Antibody Quality and Performance Guarantee
| Mouse anti Human Integrin alpha 7 antibody, clone 8G2 recognizes human integrin alpha 7. Integrin alpha 7 is a 1148 amino acid ~130 kDa type 1 single pass transmembrane glycoprotein. Integrin alpha 7 is the primary receptor for laminin in myoblasts and myofibres (Ziober et al. 2015). Mutations in the ITGA7 gene can lead to the development of a form of congenital muscular dystrophy (MDCI) presenting at or near birth with hypotonia, muscle weakness and commonly, joint contractures (Hyashi et al. 1998). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Immunogen
- Recombinant protein corresponding to aa 478 - 578 of human intefrin alpha 7
- Approx. Protein Concentrations
- Ig concentration 0.5 mg/ml
- Fusion Partners
- Spleen cells from BALB/c mice were fused with cells from the Sp2/0 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
0.1 | 10 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
References for Integrin Alpha 7 antibody
-
Vinnik, A. et al. (2013) Compounds for the treatment and prevention of retroviral infections
Patent application Number PCT/US2013/061940
- RRID
- AB_2128438
- UniProt
- Q13683
- Entrez Gene
- ITGA7
- GO Terms
- GO:0004872 receptor activity
- GO:0008305 integrin complex
- GO:0007160 cell-matrix adhesion
- GO:0007229 integrin-mediated signaling pathway
- GO:0007517 muscle organ development
- GO:0008360 regulation of cell shape
MCA5238Z
151961
170925
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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