IL-17A/F antibody | D01-1C2
Mouse anti Human Interleukin-17A/F
- Product Type
- Monoclonal Antibody
- Clone
- D01-1C2
- Isotype
- IgG1
- Specificity
- IL-17A/F
Antibody Quality and Performance Guarantee
| Mouse anti Human interleukin-17A/F antibody, clone D01-1C2, recognizes interleukin-17 A and F. The IL-17 family consists of six proteins (IL-17A to IL-17F) which function as proinflammatory cytokines, important for defence against pathogens (Gurczynski and Moore, 2017). Accordingly, IL-17-producing CD4+ T helper cells, also called Th17 cells, play important roles in immune defense. Uncontrolled IL-17 signaling is associated with immunopathology, autoimmune diseases, and cancer, and blocking activity of IL-17 can be beneficial in some clinical settings (Amatya et al. 2017). This antibody recognizes IL-17A, the most studied member of the IL-17 family, and its closest relative IL-17F (Chen and Kolls 2017). These two proteins have similar structure and inflammatory function, but unique functions of IL-17F in the immune system have also been indicated (Chang and Dong, 2009). The purified Mouse anti Human interleukin-17A/F antibody, clone D01-1C2 (MCA6206GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-17A/F antibody, clone I07-5E4 (MCA6207B) as the detection antibody. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- E. coli derived recombinant human full length interleukin-17A/F (Gly24-Ala155)
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse anti Human Interleukin-17A/F:Biotin | MCA6207B | E | 0.1 mg |
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| Description | Mouse anti Human Interleukin-17A/F:Biotin | ||||||
- UniProt
- Q16552
- Q96PD4
- Entrez Gene
- IL17A
- IL17F
- GO Terms
- GO:0001775 cell activation
- GO:0006915 apoptosis
- GO:0005125 cytokine activity
- GO:0005615 extracellular space
- GO:0006486 protein glycosylation
- GO:0006954 inflammatory response
- GO:0006955 immune response
- GO:0007267 cell-cell signaling
- GO:0032747 positive regulation of interleukin-23 production
- View More GO Terms
- GO:0045672 positive regulation of osteoclast differentiation
- GO:0045944 positive regulation of transcription from RNA polymerase II promoter
- GO:0006029 proteoglycan metabolic process
- GO:0016525 negative regulation of angiogenesis
- GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
- GO:0019955 cytokine binding
- GO:0042109 lymphotoxin A biosynthetic process
- GO:0042803 protein homodimerization activity
- GO:0045076 regulation of interleukin-2 biosynthetic process
- GO:0045408 regulation of interleukin-6 biosynthetic process
- GO:0045414 regulation of interleukin-8 biosynthetic process
- GO:0045423 regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
- GO:0051216 cartilage development
MCA6206GA
100005089
100007053
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
View more products with IL-17 specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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