Mouse anti Human interleukin-11 antibody, clone D08-4C12,
recognizes interleukin-11 (IL-11), also known as AGIF. IL-11 belongs to the IL-6 family of cytokines, and plays a protective role in acute inflammatory settings (Traber et al. 2019
). IL-11 has both pro- and anti-inflammatory functions through activation of signaling cascades (Lokau et al. 2017
). IL-11 is largely absent in the body fluids of healthy people, but is upregulated in a series of diseases. IL-11 can be expressed in fibroblasts, and its inhibition has been suggested as a treatment for fibrotic disease (Schafer et al. 2017
), including fibrotic cardiovascular diseases (Ye et al. 2019
). A role of IL-11 has also been identified in development of inflammation-associated cancers, and its inhibition may be a therapeutic goal (Putoczki et al. 2013
The purified Mouse anti Human interleukin-11 antibody, clone D08-4C12 (MCA6204GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-11 antibody, clone C16-4B8 (MCA6205B
) as the detection antibody.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of IL-11 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.