IL-11 antibody | D08-4C12
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E ResetMouse anti Human Interleukin-11
- Product Type
- Monoclonal Antibody
- Clone
- D08-4C12
- Isotype
- IgG1
- Specificity
- IL-11
| Mouse anti Human interleukin-11 antibody, clone D08-4C12, recognizes interleukin-11 (IL-11), also known as AGIF. IL-11 belongs to the IL-6 family of cytokines, and plays a protective role in acute inflammatory settings (Traber et al. 2019). IL-11 has both pro- and anti-inflammatory functions through activation of signaling cascades (Lokau et al. 2017). IL-11 is largely absent in the body fluids of healthy people, but is upregulated in a series of diseases. IL-11 can be expressed in fibroblasts, and its inhibition has been suggested as a treatment for fibrotic disease (Schafer et al. 2017), including fibrotic cardiovascular diseases (Ye et al. 2019). A role of IL-11 has also been identified in development of inflammation-associated cancers, and its inhibition may be a therapeutic goal (Putoczki et al. 2013). The purified Mouse anti Human interleukin-11 antibody, clone D08-4C12 (MCA6204GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-11 antibody, clone C16-4B8 (MCA6205B) as the detection antibody. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- E. coli derived recombinant human full length interleukin-11 (Pro22-Leu199)
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
- ELISA Matched Pair(s)
-
ELISA Matched Pair-Detection Antibody:
MCA6205B
ELISA Antigen-Positive Control:
PHP303
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse anti Human Interleukin-11:Biotin | MCA6205B | E | 0.1 mg |
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| Description | Mouse anti Human Interleukin-11:Biotin | ||||||
| Recombinant Human Interleukin-11 | PHP303 | E | 10 µg |
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| Description | Recombinant Human Interleukin-11 | ||||||
- Synonyms
- Agif
- UniProt
- P20809
- Entrez Gene
- IL11
- GO Terms
- GO:0005125 cytokine activity
- GO:0005142 interleukin-11 receptor binding
- GO:0005615 extracellular space
- GO:0007267 cell-cell signaling
- GO:0008083 growth factor activity
- GO:0008284 positive regulation of cell proliferation
- GO:0030168 platelet activation
- GO:0030183 B cell differentiation
- GO:0030219 megakaryocyte differentiation
- View More GO Terms
- GO:0033138 positive regulation of peptidyl-serine phosphorylation
- GO:0043410 positive regulation of MAPKKK cascade
- GO:0045444 fat cell differentiation
- GO:0045944 positive regulation of transcription from RNA polymerase II promoter
- GO:0046888 negative regulation of hormone secretion
- GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
MCA6204GA
100005088
100006916
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