IFN Beta antibody | F03-2G4
Mouse anti Human IFN Beta
- Product Type
- Monoclonal Antibody
- Clone
- F03-2G4
- Isotype
- IgG1
- Specificity
- IFN Beta
Antibody Quality and Performance Guarantee
| Mouse anti Human IFN beta antibody, clone F03-2G4, recognizes interferon beta (IFN beta) also known as fibroblast interferon, a type I interferon. It is constitutively expressed, but is synthesized at a higher level upon infection (Takaoka & Taniguchi 2003). IFN beta plays many roles within inflammation including limiting the immune response during inflammation through induction of IL-10 and can inhibit the inflammasome and IL-1 beta. It can also play a role in the reprogramming of macrophages to an inflammatory and pro-resolving phenotype (Satyanarayanan et al. 2019). These responses are mediated through its interaction with the IFN alpha/beta receptor with subsequent downstream activation of STAT1, 2 or 3 (Takaoka & Taniguchi 2003). Beyond inflammation IFN beta has been observed to block cancer progression by reducing the recruitment of pro-angiogenic neutrophils into tumors (Andzinski et al. 2015). The purified Mouse anti Human IFN beta antibody, clone F03-2G4 (MCA6236GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human IFN beta antibody, clone C06-4F6 (MCA6237B) as the detection antibody. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- E. coli derived recombinant human full length IFN beta (Met22-Asn187)
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse anti Human IFN Beta:Biotin | MCA6237B | E | 0.1 mg |
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| Description | Mouse anti Human IFN Beta:Biotin | ||||||
- Synonyms
- Fibroblast Interferon
- UniProt
- P01574
- Entrez Gene
- IFNB1
- GO Terms
- GO:0003714 transcription corepressor activity
- GO:0007596 blood coagulation
- GO:0005125 cytokine activity
- GO:0005132 interferon-alpha/beta receptor binding
- GO:0005615 extracellular space
- GO:0006917 induction of apoptosis
- GO:0006919 activation of caspase activity
- GO:0008285 negative regulation of cell proliferation
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- View More GO Terms
- GO:0030101 natural killer cell activation
- GO:0032897 negative regulation of viral transcription
- GO:0042100 B cell proliferation
- GO:0045071 negative regulation of viral genome replication
- GO:0045089 positive regulation of innate immune response
- GO:0045343 regulation of MHC class I biosynthetic process
- GO:0046597 negative regulation of virion penetration into host cell
- GO:0051607 defense response to virus
- GO:0060337 type I interferon-mediated signaling pathway
- GO:0060338 regulation of type I interferon-mediated signaling pathway
- GO:0071360 cellular response to exogenous dsRNA
MCA6236GA
100005375
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
View more products with IFN BETA specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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