IFN Beta antibody | BB4
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Mouse anti Human IFN beta antibody, clone BB4 recognizes human interferon beta (IFN Beta), a ~22 kDa cytokine with wide-ranging antiviral, antimicrobial and antitumor effects. Interferons also serve to activate macrophages, natural killer cells and the presentation of antigens to the immune system by the major histocompatibility complex. The production of interferon is induced in response to microbes and other cytokines. The interferons are widely used to treat a variety of diseases and IFNB in particular is used to treat relapsing-remitting multiple sclerosis.
Mouse anti Human IFN beta antibody, clone BB4 recognizes glycosylated and non-glycosylated human IFNβ and there is no cross-reactivity with human interferon alpha or human interferon gamma.
Mouse anti Human IFN beta antibody, clone BB4 recognizes glycosylated and non-glycosylated human IFNβ and there is no cross-reactivity with human interferon alpha or human interferon gamma.
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Immunogen
- Recombinant full size human IFN Beta, expressed in E.coli.
- Approx. Protein Concentrations
- IgG concentration 1 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the Sp2/0 myeloma cell line.
Storage Information
- Storage
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P01574
- Entrez Gene
- IFNB1
- GO Terms
- GO:0003714 transcription corepressor activity
- GO:0007596 blood coagulation
- GO:0005125 cytokine activity
- GO:0005132 interferon-alpha/beta receptor binding
- GO:0005615 extracellular space
- GO:0006917 induction of apoptosis
- GO:0006919 activation of caspase activity
- GO:0008285 negative regulation of cell proliferation
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0030101 natural killer cell activation
- GO:0032897 negative regulation of viral transcription
- GO:0042100 B cell proliferation
- GO:0045071 negative regulation of viral genome replication
- GO:0045089 positive regulation of innate immune response
- GO:0045343 regulation of MHC class I biosynthetic process
- GO:0046597 negative regulation of virion penetration into host cell
- GO:0051607 defense response to virus
- GO:0060337 type I interferon-mediated signaling pathway
- GO:0060338 regulation of type I interferon-mediated signaling pathway
- GO:0071360 cellular response to exogenous dsRNA
- Regulatory
- For research purposes only
Applications of IFN Beta antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | |||
| Western Blotting |
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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