IFN Beta antibody | BB4

Mouse anti Human IFN Beta

Product Type
Monoclonal Antibody
Clone
BB4
Isotype
IgG2a
Specificity
IFN Beta

Product Code Applications Pack Size List Price Your Price Qty
MCA2762
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E WB 0.2 mg loader
List Price Your Price
loader
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Mouse anti Human IFN beta antibody, clone BB4 recognizes human interferon beta (IFN Beta), a ~22 kDa cytokine with wide-ranging antiviral, antimicrobial and antitumor effects. Interferons also serve to activate macrophages, natural killer cells and the presentation of antigens to the immune system by the major histocompatibility complex. The production of interferon is induced in response to microbes and other cytokines. The interferons are widely used to treat a variety of diseases and IFNB in particular is used to treat relapsing-remitting multiple sclerosis.

Mouse anti Human IFN beta antibody, clone BB4 recognizes glycosylated and non-glycosylated human IFNβ and there is no cross-reactivity with human interferon alpha or human interferon gamma.

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
Immunogen
Recombinant full size human IFN Beta, expressed in E.coli.
Approx. Protein Concentrations
IgG concentration 1 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the Sp2/0 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Western Blotting
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

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Synonyms
Interferon Beta
RRID
AB_1102700
UniProt
P01574
Entrez Gene
IFNB1
GO Terms
GO:0003714 transcription corepressor activity
GO:0007596 blood coagulation
GO:0005125 cytokine activity
GO:0005132 interferon-alpha/beta receptor binding
GO:0005615 extracellular space
GO:0006917 induction of apoptosis
GO:0006919 activation of caspase activity
GO:0008285 negative regulation of cell proliferation
GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
GO:0030101 natural killer cell activation
GO:0032897 negative regulation of viral transcription
GO:0042100 B cell proliferation
GO:0045071 negative regulation of viral genome replication
GO:0045089 positive regulation of innate immune response
GO:0045343 regulation of MHC class I biosynthetic process
GO:0046597 negative regulation of virion penetration into host cell
GO:0051607 defense response to virus
GO:0060337 type I interferon-mediated signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0071360 cellular response to exogenous dsRNA
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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