Mouse anti Human galectin-8 antibody, clone 106.1,
recognizes galectin-8 also known as Po66 carboxyhydrate binding protein. Galectin-8 expressed in many tissues including kidney, liver, cardiac muscle, lung, breast, colon, retina, pancreas, placenta, spleen, testis, uterus, vascular esophagus and brain (Hadari et al. 1995
Galectin-8 is a member of the galactin family of proteins which cross-link cell surface glycol proteins in the extracellular space upon secretion and plays a role in many biological processes including cell growth and migration. Studies have shown that galectin-8 can either positively or negatively regulate cell adhesion, depending on the extracellular context. When at high concentrations galectin-8 has also been shown to trigger antigen independent proliferation of CD4+
T cells. While at low levels galectin-8 can act in a co-stimulatory signaling capacity that synergizes antigen specific CD4+
T cell responses (Metz et al. 2016
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Galectin-8 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.