GAB1 antibody | F01/9A4-2
Mouse anti Human GAB1
- Product Type
- Monoclonal Antibody
- Clone
- F01/9A4-2
- Isotype
- IgG1
- Specificity
- GAB1
Antibody Quality and Performance Guarantee
| Mouse anti human GAB1 antibody, clone F01/9A4-2 recognizes GRB2-associated-binding protein 1, also known as GAB1, GRB2-associated binder 1 or Growth factor receptor bound protein 2-associated protein 1 when phosphorylated at tyrosine 627. GAB1 is a docking protein capable of interactions with several different proteins particularly the activation of receptor tyrosine kinase signaling. Phosphorylation of GAB1 at tyrosine 627 leads to SHP2 recruitment and subsequent activation of MAPK signaling. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- E. coli-derived recombinant protein, aa 243-694 of human GAB1.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1,000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Mouse anti human GAB1 detects a band of approximately 102 kDa in HepG2 cell lysates.
- UniProt
- Q13480
- Entrez Gene
- GAB1
- GO Terms
- GO:0005829 cytosol
- GO:0005070 SH3/SH2 adaptor activity
- GO:0007173 epidermal growth factor receptor signaling pathway
- GO:0008283 cell proliferation
- GO:0008286 insulin receptor signaling pathway
- GO:0008543 fibroblast growth factor receptor signaling pathway
MCA6433GA
100007873
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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