FES antibody | AB04-4F6
Mouse anti Human FES
- Product Type
- Monoclonal Antibody
- Clone
- AB04-4F6
- Isotype
- IgG1
- Specificity
- FES
Antibody Quality and Performance Guarantee
| Mouse anti human FES antibody, clone AB04-4F6
recognizes tyrosine-protein kinase FES/FPS, otherwise known as feline sarcoma/fujinami avian sarcoma oncogene homolog, proto-oncogene c-FES, proto-oncogene c-FPS or p93c-FES. FES is one of two members of a unique family of cytoplasmic protein tyrosine kinases, alongside tyrosine-protein kinase FER. This family of kinases contains a central src homology-2 (SH2) domain and a COOH-terminal tyrosine kinase catalytic domain and are distinct from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of NH2-terminal FER/CIP4 homology and coiled-coil domains (Sangrar et al. 2005). Studies initially suggested that mutations in FES contribute to the development of some cancers (Ley et al. 2003). However, more recent research has shown that FES may act a tumor suppressor in colorectal cancer (Delfino et al. 2006). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- E. coli-derived recombinant protein, aa 1-459 of human FES
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1,000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Mouse anti Human FES antibody detects a band of 94 kDa in THP-1 cell lysate
- UniProt
- P07332
- Entrez Gene
- FES
- GO Terms
- GO:0005829 cytosol
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005524 ATP binding
- GO:0007411 axon guidance
- GO:0008283 cell proliferation
- GO:0018108 peptidyl-tyrosine phosphorylation
MCA6412GA
100007677
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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