ERRFI1 antibody | CD02-3E1
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WB ResetMouse anti Human ERRFI1
- Product Type
- Monoclonal Antibody
- Clone
- CD02-3E1
- Isotype
- IgG1
- Specificity
- ERRFI1
Antibody Quality and Performance Guarantee
MCA6413GA
| Mouse anti human ERRFI1 antibody, clone CD02-3E1 recognizes ERBB receptor feedback inhibitor 1, otherwise known as mitogen-inducible gene 6 protein (MIG-6). Expression of ERRFI1 has been shown to increase in the cytoplasm of growing cells (Wick et al. 1995). ERRFI1 shares significant homology with the protein product of rat gene-33, expression of which is increased in response to cell stress (Makkinje et al. 2000). ERRFI1 is involved in the regulation of EGFR signaling (Xu et al. 2005). Additionally, in response to stress, ERRFI1 has been shown to mediate response to DNA damage through ATM serine/threonine kinases (Li et al. 2017). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- E. coli-derived recombinant protein, aa 1-462 of human ERRFI1
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1,000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Mouse anti Human ERRFI1 antibody detects a band of 55 kDa in HepG2 cell lysates
- UniProt
- Q9UJM3
- Entrez Gene
- ERRFI1
- GO Terms
- GO:0005100 Rho GTPase activator activity
- GO:0007175 negative regulation of epidermal growth factor receptor activity
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0006950 response to stress
- GO:0019901 protein kinase binding
- GO:0031234 extrinsic to internal side of plasma membrane
- GO:0031953 negative regulation of protein autophosphorylation
- GO:0043589 skin morphogenesis
- View More GO Terms
- GO:0045616 regulation of keratinocyte differentiation
- GO:0048286 lung alveolus development
- GO:0060426 lung vasculature development
- GO:0060428 lung epithelium development
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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