D-Dimer antibody | DD1
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Mouse anti Human D-Dimer
- Product Type
- Monoclonal Antibody
- Clone
- DD1
- Isotype
- IgG2a
- Specificity
- D-Dimer
Antibody Quality and Performance Guarantee
| Mouse anti Human D-Dimer antibody, clone DD1 recognizes human D-dimer and high molecular weight fibrin degradation products, but does not cross-react with fibrinogen (D-monomer). D-dimers are the principle degradation products of cross-linked fibrin, released into the bloodstream following the digestion of fibrin clots (thrombus) by the enzyme plasmin, and thus measurement of the level of D-dimer in plasma, can be used as an indication of thrombotic disorders. Conditions in which levels of D-dimer are elevated include deep vein thrombosis (DVT), venous thromboembolism (VTE), cardiovascular disease and disseminated intravascular coagulation (DIC), a possible acute condition arising from surgical operations, septic shock and liver disease. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Immunogen
- Homogenised fibrin clot.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Fusion Partners
- Spleen cells from immunized Balb/c mice were fused with cells of the Sp2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
||
| Western Blotting | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
References for D-Dimer antibody
-
Ibupoto, Z.H. et al. (2014) The Development of Highly Sensitive and Selective Immunosensor Based on Antibody Immobilized ZnO Nanorods for the Detection of D-Dimer
Electroanalysis. 26 (2): 292-8. -
Georgia-Paraskei, N. et al. (2014) A Selective Immunosensor for D-dimer Based on Antibody Immobilized on a Graphene Electrode with Incorporated Lipid Films
Electroanalysis. 26 (7): 1522-7. -
Zamolodchikov, D. et al. (2016) The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII.
J Thromb Haemost. 14 (5): 995-1007.
Further Reading
-
Kruskal, J.B. et al. (1992) Elevated fibrin-related and fibrinogen-related antigens in patients with liver disease.
Hepatology. 16 (4): 920-3.
- RRID
- AB_609617
- UniProt
- P02671
- P02675
- P02679
- Entrez Gene
- FGA
- FGB
- FGG
- GO Terms
- GO:0002576 platelet degranulation
- GO:0030674 protein binding, bridging
- GO:0005102 receptor binding
- GO:0007165 signal transduction
- GO:0005577 fibrinogen complex
- GO:0009897 external side of plasma membrane
- GO:0030168 platelet activation
- GO:0031093 platelet alpha granule lumen
- GO:0043499 eukaryotic cell surface binding
- View More GO Terms
- GO:0051258 protein polymerization
- GO:0051592 response to calcium ion
- GO:0051087 chaperone binding
- GO:0005625 soluble fraction
MCA2523
155665
157893
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