D-Dimer antibody | DD1
D-dimers are the principle degradation products of cross-linked fibrin, released into the bloodstream following the digestion of fibrin clots (thrombus) by the enzyme plasmin, and thus measurement of the level of D-dimer in plasma, can be used as an indication of thrombotic disorders. Conditions in which levels of D-dimer are elevated include deep vein thrombosis (DVT), venous thromboembolism (VTE), cardiovascular disease and disseminated intravascular coagulation (DIC), a possible acute condition arising from surgical operations, septic shock and liver disease.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide (NaN3)
- Homogenised fibrin clot.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Fusion Partners
- Spleen cells from immunized Balb/c mice were fused with cells of the Sp2/0 myeloma cell line
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch.
- Entrez Gene
- GO Terms
- GO:0002576 platelet degranulation
- GO:0030674 protein binding, bridging
- GO:0005102 receptor binding
- GO:0007165 signal transduction
- GO:0005577 fibrinogen complex
- GO:0009897 external side of plasma membrane
- GO:0030168 platelet activation
- GO:0031093 platelet alpha granule lumen
- GO:0043499 eukaryotic cell surface binding
- GO:0051258 protein polymerization
- GO:0051592 response to calcium ion
- GO:0051087 chaperone binding
- GO:0005625 soluble fraction
- For research purposes only
Applications of D-Dimer antibody
|Application Name||Verified||Min Dilution||Max Dilution|
Secondary Antibodies Available
Product Specific References
References for D-Dimer antibody
Kruskal, J.B. et al. (1992) Elevated fibrin-related and fibrinogen-related antigens in patients with liver disease.
Hepatology. 16 (4): 920-3.
Zamolodchikov, D. et al. (2016) The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII.
J Thromb Haemost. 14 (5): 995-1007.
IbupotoZafar, H. et al. (2014) The Development of Highly Sensitive and Selective Immunosensor Based on Antibody Immobilized ZnO Nanorods for the Detection of D-Dimer
Electroanalysis. 26 (2): 292-8.
Georgia-Paraskei, N. et al. (2014) A Selective Immunosensor for D-dimer Based on Antibody Immobilized on a Graphene Electrode with Incorporated Lipid Films
Electroanalysis. 26 (7): 1522-7.