Cystatin C antibody | Cyst10
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Mouse anti Human Cystatin C
- Product Type
- Monoclonal Antibody
- Clone
- Cyst10
- Isotype
- IgG3
- Specificity
- Cystatin C
Antibody Quality and 
Unrivaled 
| Mouse anti Human Cystatin C antibody, clone Cyst10 detects human Cystatin C, a member of the type 2 cystatin superfamily. Cystatin C is a potent inhibitor of cysteine proteinases, both endogenous (lysosomal cathepsins), and pathogenic. Cystatin C is a 13 kDa secreted protein which is found in high concentrations in biological fluids and is thought to be expressed by all human nucleated cells. Changes in cystatin C have been documented in a number of cardiovascular diseases, including atherosclerosis, amyloid angiopathy and myocardial infarction. Its low molecular weight also means that Cystatin C can be used as a marker of renal failure. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Fusion Partners
- Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
References for Cystatin C antibody
-
Mussap, M. & Plebani, M. (2004) Biochemistry and clinical role of human cystatin C.
Crit Rev Clin Lab Sci. 41 (5-6): 467-550. -
Filler, G. et al. (2005) Cystatin C as a marker of GFR--history, indications, and future research.
Clin Biochem. 38 (1): 1-8.
- RRID
- AB_2088050
- UniProt
- P01034
- Entrez Gene
- CST3
- GO Terms
- GO:0001540 beta-amyloid binding
- GO:0002020 protease binding
- GO:0006952 defense response
- GO:0004869 cysteine-type endopeptidase inhibitor activity
- GO:0005615 extracellular space
- GO:0010703 negative regulation of histolysis
- GO:0010711 negative regulation of collagen catabolic process
- GO:0010716 negative regulation of extracellular matrix disassembly
- GO:0043206 fibril organization
- View More GO Terms
- GO:0060311 negative regulation of elastin catabolic process
- GO:0060313 negative regulation of blood vessel remodeling
View more products with Cystatin C specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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