Cyld antibody | CD02/3E12-1
Mouse anti Human Cyld
- Product Type
- Monoclonal Antibody
- Clone
- CD02/3E12-1
- Isotype
- IgG1
- Specificity
- Cyld
Antibody Quality and Performance Guarantee
| Mouse anti human CYLD antibody, clone CD02/3E12-1 recognizes ubiquitin carboxyl-terminal hydrolase CYLD protein, also known as CYLD1 or KIAA0849. CYLD is a tumor suppressor, and is associated with skin appendage tumors such as familial cylindromatosis and multiple familial trichoepithelioma (Sun, 2009). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- E. coli-derived recombinant protein, aa 1-491 of human CYLD.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1,000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Mouse anti human CYLD detects a band of approximately 111 kDa in Jurkat cell lysates.
- UniProt
- Q9NQC7
- Entrez Gene
- CYLD
- GO Terms
- GO:0003735 structural constituent of ribosome
- GO:0004221 ubiquitin thiolesterase activity
- GO:0005829 cytosol
- GO:0004843 ubiquitin-specific protease activity
- GO:0016055 Wnt receptor signaling pathway
- GO:0005840 ribosome
- GO:0005874 microtubule
- GO:0006412 translation
- GO:0006511 ubiquitin-dependent protein catabolic process
- View More GO Terms
- GO:0007049 cell cycle
- GO:0007346 regulation of mitotic cell cycle
- GO:0008270 zinc ion binding
- GO:0019901 protein kinase binding
- GO:0031234 extrinsic to internal side of plasma membrane
- GO:0032088 negative regulation of NF-kappaB transcription factor activity
- GO:0032480 negative regulation of type I interferon production
- GO:0042347 negative regulation of NF-kappaB import into nucleus
- GO:0048471 perinuclear region of cytoplasm
- GO:0070064 proline-rich region binding
- GO:0070507 regulation of microtubule cytoskeleton organization
- GO:0070536 protein K63-linked deubiquitination
- GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
MCA6430GA
100007870
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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