Complement Factor P antibody | 062-27.8.1 (10-18)
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|Mouse anti Human Factor P antibody, clone 062-27.8.1 (10-18) recognizes human factor P, a 53 kDa glycosylated protein present in blood serum. Factor P binds to microbial surfaces and binds and stabilizes the complement component 3- and complement component 5-convertase enzyme complexes. C3b then acts as an opsonin or initiates the complement pathway again creating a positive feedback loop which acts only on the bacterial cell, leaving the host cells unharmed. Deficiency of factor P makes the host more susceptible to bacterial infections, particularly to Neisseria species and meningococcal infections.
Mouse anti Human Factor P antibody, clone 10-18 is reported to inhibit the function of factor P. Removal of sodium azide is recommended prior to use in functional assays.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Native purified factor P from human serum.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- For research purposes only
- Guaranteed until date of expiry. Please see product label.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen||1:1000|
- Histology Positive Control Tissue
- Kidney from post streptoccal glomerulonephritis patients
Hourcade, D.E. (2006) The role of properdin in the assembly of the alternative pathway C3 convertases of complement.
J Biol Chem. 281 (4): 2128-32.
Jelezarova, E. et al. (2000) Interaction of C3b(2)--IgG complexes with complement proteins properdin, factor B and factor H: implications for amplification.
Biochem J. 349 (Pt 1): 217-23.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"View all Anti-Human Products
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