Clusterin antibody | 3R3/2

Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimer's disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells.
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Immunogen
- Glomerular basement membrane from a post-mortem kidney.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 18 months from date of despatch.
More Information
- UniProt
- P10909 Related reagents
- Entrez Gene
- CLU Related reagents
- GO Terms
- GO:0001836 release of cytochrome c from mitochondria
- GO:0002576 platelet degranulation
- GO:0009615 response to virus
- GO:0005739 mitochondrion
- GO:0006629 lipid metabolic process
- GO:0006958 complement activation, classical pathway
- GO:0051787 misfolded protein binding
- GO:0030168 platelet activation
- GO:0031093 platelet alpha granule lumen
- GO:0032463 negative regulation of protein homooligomerization
- GO:0034366 spherical high-density lipoprotein particle
- GO:0043691 reverse cholesterol transport
- GO:0045087 innate immune response
- GO:0051788 response to misfolded protein
- Regulatory
- For research purposes only
Applications of Clusterin antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | |||
Flow Cytometry | |||
Immunohistology - Frozen | |||
Western Blotting |
- Histology Positive Control Tissue
- Kidney from post streptocial glomerulonephritis patients.
Secondary Antibodies Available
Negative Isotype Controls Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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Product Specific References
References for Clusterin antibody
-
Kumita, J.R. et al. (2007) The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.
J Mol Biol. 369 (1): 157-67. -
Shannan, B. et al. (2006) Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control.
J Mol Histol. 37 (5-7): 183-8.