CD93 antibody | rA50B50-02/1F3
Mouse anti Human CD93
- Product Type
- Monoclonal Antibody
- Clone
- rA50B50-02/1F3
- Isotype
- IgG1
- Specificity
- CD93
Antibody Quality and Performance Guarantee
TZA0169GA
Recombinant Antibodies
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| Mouse anti Human CD93 antibody, clone rA50B50-02/1F3, is a recombinant monoclonal antibody that recognizes CD93, also known as Complement component C1q receptor, C1qR1 or C1qRp. CD93 is a single-pass type I transmembrane glycoprotein part of the C-type lectin domain (CTLD) group 14 family. It is predominantly expressed on endothelial cells but is also expressed by hematopoietic stem cells, monocytes, neutrophils, B cells, natural killer cells and platelets. CD93 regulates a range of physiological processes such as angiogenesis, cell adhesion, cell migration and clearance of apoptotic cells by interacting multimerin-2 and insulin-like growth factor-binding protein 7. In B cells, CD93 expression maintains antibody secretion. Despite its name, CD93 does not directly engage with C1q. CD93 dysregulation has been reported in various conditions, including inflammation, autoimmune disorders, cancer and cardiovascular disease. CD93 is highly expressed in tumor-associated blood vessels and is correlated with poor prognosis and advanced disease. |
- Target Species
- Human
- Product Form
- Purified recombinant IgG containing a SpyTag at the C-terminus of the antibody heavy chain – liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Source
- CHO cells
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Recombinant CD93 aa 24-580 expressed by mammalian cells
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 5μl of the suggested working dilution to label 0.5x106 cells in 100μl. Best practices suggest a 5 min centrifugation at 6,000g prior to sample application.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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| List Price | Your Price | ||||||
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| Description | Mouse IgG1 Negative Control | ||||||
- UniProt
- Q9NPY3
- Entrez Gene
- CD93
- GO Terms
- GO:0005886 plasma membrane
- GO:0005509 calcium ion binding
- GO:0001849 complement component C1q binding
- GO:0016021 integral to membrane
- GO:0004872 receptor activity
- GO:0005529 sugar binding
- GO:0006909 phagocytosis
- GO:0016337 cell-cell adhesion
- GO:0042116 macrophage activation
- View More GO Terms
- GO:0044419 interspecies interaction between organisms
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