CD79b antibody | AT105-1
Mouse anti Human CD79b
- Product Type
- Monoclonal Antibody
- Clone
- AT105-1
- Isotype
- IgG1
- Specificity
- CD79b
Antibody Quality and Performance Guarantee
| Mouse anti Human CD79b antibody, clone AT105-1 recognizes an extracellular region of human B-cell antigen receptor complex-associated protein beta chain, also known as CD79b, B-cell-specific glycoprotein B29, Ig-beta or,
Immunoglobulin-associated B29. CD79b is a cell surface antigen expressed by B lymphocytes and associates with CD79a to form a heterodimer, non-covalently linked to surface immunoglobulin, forming the B-cell receptor (BCR) complex. Mutations in the CD79B gene can lead to presentation of Agammaglobulinemia 6, autosomal recessive (AGM6), a disease demonstrating low or absent circulating B cells with the concomitant absence of antibody production. Patients present with multiple severe infections early in life (Dobbs et al. 2007). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
- Immunogen
- Peptide corresponding to an extracellular region of CD79 beta
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised mouse were fused with cells of the mouse NS-1 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
1/50 | 1/100 |
| Immunoprecipitation | |
||
| Western Blotting | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 106 cells in 100μl
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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| List Price | Your Price | ||||||
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| Description | Mouse IgG1 Negative Control | ||||||
References for CD79b antibody
-
Cragg, M.S. et al. (2002) The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis.
Blood. 100 (9): 3068-76. -
Zheng, B. et al. (2009) In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates.
Mol Cancer Ther. 8 (10): 2937-46.
- Synonyms
- B29
- RRID
- AB_324061
- UniProt
- P40259
- Entrez Gene
- CD79B
- GO Terms
- GO:0004888 transmembrane receptor activity
- GO:0005887 integral to plasma membrane
- GO:0005634 nucleus
- GO:0005794 Golgi apparatus
- GO:0006955 immune response
- GO:0007166 cell surface receptor linked signaling pathway
View more products with CD79b specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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