CD66e antibody | CB30
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Mouse anti Human CD66e antibody, clone CB30 recognizes human CD66e, also known as carcinoembryonic antigen (CEA).
CD66e is a member of the immunoglobulin supergene family that is mainly expressed on epithelial cells. CD66e may play a role in cancer cells metastasis, and has been used clinically as a tumor marker for early detection of disease.
CD66e is a member of the immunoglobulin supergene family that is mainly expressed on epithelial cells. CD66e may play a role in cancer cells metastasis, and has been used clinically as a tumor marker for early detection of disease.
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide (NaN3) - Carrier Free
- Yes
- Immunogen
- Human carcinoembryonic antigen.
- Approx. Protein Concentrations
- 1.0 mg/ml
Storage Information
- Storage
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P06731
- Entrez Gene
- CEACAM5
- GO Terms
- GO:0005887 integral to plasma membrane
- GO:0031225 anchored to membrane
- GO:0016323 basolateral plasma membrane
- Regulatory
- For research purposes only
Applications of CD66e antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry | |||
| Immunohistology - Frozen | |||
| Immunohistology - Paraffin 1 | 1/100 | 1/200 | |
| Immunoprecipitation |
- 1This product requires protein digestion pre-treatment of paraffin sections e.g. pronase.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Adenocarcinoma of colon.
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Secondary Antibodies Available
Negative Isotype Controls Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
|
Product Specific References
References for CD66e antibody
-
Horenstein, A.L. et al. (2003) Design and scaleup of downstream processing of monoclonal antibodies for cancer therapy: from research to clinical proof of principle.
J Immunol Methods. 275 (1-2): 99-112. -
Manini, I. et al. (2020) Heterogeneity Matters: Different Regions of Glioblastoma Are Characterized by Distinctive Tumor-Supporting Pathways.
Cancers (Basel). 12 (10)Oct 13 [Epub ahead of print].
Further Reading
-
Thompson, J.A. et al. (1991) Carcinoembryonic antigen gene family: molecular biology and clinical perspectives.
J Clin Lab Anal. 5 (5): 344-66.
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