CD66c antibody | rA19B19-08-1G8
Mouse anti Human CD66c
- Product Type
- Monoclonal Antibody
- Clone
- rA19B19-08-1G8
- Isotype
- IgG1
- Specificity
- CD66c
Antibody Quality and Performance Guarantee
TZA0131GA
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| Mouse anti Human CD66c antibody, clone rA19B19-08/1G8, is a recombinant monoclonal antibody that recognizes CD66c, also known as cell adhesion molecule CEACAM6. CD66c is a member of the carcinoembryonic antigen (CEA) family, which is involved in a range of cellular processes through homotypic and heterotypic interactions. CD66c contains an N-terminal region homologous to the immunoglobulin variable domain, two domains homologous to the immunoglobulin constant domain and is linked to the membrane via a GPI anchor. CD66c is expressed in a range of organs, including the gallbladder, liver, colon, stomach, skin and tongue. CD66c has been shown to regulate anoikis through activation of the Src-FAK signaling system. CD66c expression is increased in Crohn’s disease and ulcerative colitis. It is a receptor for adherent invasive E.coli that promotes the inflammation associated with inflammatory bowel disease. CD66c expression is significantly increased in malignancies, is important for the metastatic potential of cancers and is reported to be a useful prognostic tool for cancer. |
- Target Species
- Human
- Product Form
- Purified recombinant IgG containing a SpyTag at the C-terminus of the antibody heavy chain – liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Source
- CHO cells
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Recombinant CD66c Lys35-Gly320 expressed by mammalian cells
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 5μl of the suggested working dilution to label 0.5x106 cells in 100μl. Best practices suggest a 5 min centrifugation at 6,000g prior to sample application.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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| List Price | Your Price | ||||||
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| Description | Mouse IgG1 Negative Control | ||||||
- Synonyms
- CEACAM6
- UniProt
- P40199
- Entrez Gene
- CEACAM6
- GO Terms
- GO:0007165 signal transduction
- GO:0005887 integral to plasma membrane
- GO:0007267 cell-cell signaling
- GO:0031225 anchored to membrane
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