CD49a antibody | TS2/7
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|Mouse anti Human CD49a antibody, clone TS2/7 recognizes the human alpha 1 integrin sub-unit, which forms the VLA-1 heterodimer in association with the beta 1 integrin. VLA-1 is a receptor for collagen and laminin, and is expressed by chronically activated T cells, melanoma cells and smooth muscle cells.
Mouse anti Human CD49a antibody, clone TS2/7 has been reported as being suitable for use in Western Blotting.
Mouse anti Human CD49a antibody, clone TS2/7 is routinely tested in flow cytometry using HeLa cells.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide
- Carrier Free
- Human CTL line directed against HLA-DR.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunized Balb.c mice were fused with cells of the NS1 mouse myeloma.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
References for CD49a antibody
Hemler, M.E. et al. (1984) Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines.
J Immunol. 132 (6): 3011-8.
Hemler, M.E. et al. (1985) Biochemical characterization of VLA-1 and VLA-2. Cell surface heterodimers on activated T cells.
J Biol Chem. 260 (28): 15246-52.
Hafler, D.A. et al. (1985) Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases.
Clin Immunol Immunopathol. 37 (2): 163-71.
Klemmt, P.A. et al. (2007) Endometrial cells from women with endometriosis have increased adhesion and proliferative capacity in response to extracellular matrix components: towards a mechanistic model for endometriosis progression.
Hum Reprod. 22: 3139-47.
Berry, P.A. et al. (2011) The calcium sensor STIM1 is regulated by androgens in prostate stromal cells.
Prostate. 71: 1646-55.
Elshaw, S.R. et al. (2001) A comparison of ocular melanocyte and uveal melanoma cell invasion and the implication of alpha1beta1, alpha4beta1 and alpha6beta1 integrins.
Br J Ophthalmol. 85: 732-8.
Cervar-Zivkovic, M. et al. (2011) Endothelin-1 Stimulates Proliferation of First-Trimester Trophoblasts via the A- and B-Type Receptor and Invasion via the B-Type Receptor.
J Clin Endocrinol Metab. 96: 3408-15.
Kaneko, Y. et al. (2012) Integrin α1/β1 and α2/β1 as a receptor for IgA1 in human glomerular mesangial cells in IgA nephropathy.
Int Immunol. 24: 219-32.
View The Latest Product References
Majali-Martinez, A. et al. (2018) Temporal changes of the endothelin system in human cytotrophoblasts during the first trimester of pregnancy.
Physiol Res. 67 (Suppl 1): S247-S255.
Zhuang, L. et al. (2021) Dermal Pericytes Exhibit Declined Ability to Promote Human Skin Regeneration with Ageing in 3D Organotypic Culture Models
Cells. 10 (11): 3051.
- Integrin Alpha 1 Chain
- Entrez Gene
- GO Terms
- GO:0006936 muscle contraction
- GO:0004872 receptor activity
- GO:0005518 collagen binding
- GO:0008305 integrin complex
- GO:0007160 cell-matrix adhesion
- GO:0007229 integrin-mediated signaling pathway
- GO:0007411 axon guidance
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