CD42b antibody | AK2
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|Mouse anti Human CD42b antibody, clone AK2 recognizes the human CD42b cell surface antigen, also known as platelet glycoprotein GP1B.
CD42b is expressed by platelets and megakaryocytes. Clone AK2 has been reported to block the binding of von Willebrand Factor (VWF) to platelets.
- Target Species
- Product Form
- Purified IgG - liquid
- MCA740T: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- MCA740GA, MCA740: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide
- Carrier Free
- Approx. Protein Concentrations
- IgG concentration 1 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 100ul whole blood.
References for CD42b antibody
Ward, C.M. & Berndt, M.C. (1995) Epitope and functional characterization of the CD42 (gpIb/IX) mAb panel.
Leucocyte Typing V. White Cell Differentiation Antigens. Volume Two. Oxford University Press, Oxford.
Burgess, J.K. et al. (1998) Quinine-dependent antibodies bind a restricted set of epitopes on the glycoprotein Ib-IX complex: characterization of the epitopes.
Blood. 92: 2366-73.
Burgess, J.K. et al. (2000) Rifampicin-dependent antibodies bind a similar or identical epitope to glycoprotein IX-specific quinine-dependent antibodies.
Blood. 95: 1988-92.
Jayo, A. et al. (2010) L718P mutation in the membrane-proximal cytoplasmic tail of beta 3 promotes abnormal alpha IIb beta 3 clustering and lipid microdomain coalescence, and associates with a thrombasthenia-like phenotype.
Haematologica. 95: 1158-66.
Lova, P. et al. (2004) Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin.
J Biol Chem. 279: 25299-306.
Shen, Y. et al. (2000) Requirement of leucine-rich repeats of glycoprotein (GP) Ibalpha for shear-dependent and static binding of von Willebrand factor to the platelet membrane GP Ib-IX-V complex.
Blood. 95: 903-10.
Wright, S.D. et al. (1993) Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome.
Blood. 81: 2339-47.
Nomura, S. et al. (1995) Significance of cytokines and CD68-positive microparticles in immune thrombocytopenic purpura.
Eur J Haematol. 55: 49-56.
View The Latest Product References
Speich, H.E. et al. (2008) Platelets undergo phosphorylation of Syk at Y525/526 and Y352 in response to pathophysiological shear stress.
Am J Physiol Cell Physiol. 295: C1045-54.
Balduini, A. et al (2008) Adhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes.
J Thromb Haemost. 6: 1900-7.
Amor, N.B. et al. (2009) Acidic-store depletion is required for human platelet aggregation.
Blood Coagul Fibrinolysis. 20: 511-6.
Tasneem, S. et al. (2009) Platelet adhesion to multimerin 1 in vitro: influences of platelet membrane receptors, von Willebrand factor and shear.
J Thromb Haemost. 7: 685-92.
Lincoln, B. et al. (2010) Integrated system investigating shear-mediated platelet interactions with von Willebrand factor using microliters of whole blood
Anal Biochem. 405: 174-83.
Goetzl EJ et al. (2016) Human plasma platelet-derived exosomes: effects of aspirin.
FASEB J. Feb 12. pii: fj.201500150R. [Epub ahead of print]
Michalska-Jakubus, M. et al. (2016) Plasma endothelial microparticles reflect the extent of capillaroscopic alterations and correlate with the severity of skin involvement in systemic sclerosis.
Microvasc Res. Nov 23. pii: S0026-2862(16)30097-8. [Epub ahead of print]
Ralph, A. et al. (2016) Computational Tracking of Shear-Mediated Platelet Interactions with von Willebrand Factor.
Cardiovasc Eng Technol. 7 (4): 389-405.
Rossi, E. et al. (2017) Human endoglin as a potential new partner involved in platelet-endothelium interactions.
Cell Mol Life Sci. Oct 28 [Epub ahead of print].
Kim, J.S. et al. (2021) Randomization to Omega-3 Fatty Acid Supplementation and Endothelial Function in COPD: The COD-Fish Randomized Controlled Trial.
Chronic Obstr Pulm Dis. 8(1):41-53.
- Entrez Gene
- GO Terms
- GO:0005515 protein binding
- GO:0007155 cell adhesion
- GO:0005887 integral to plasma membrane
- GO:0005624 membrane fraction
- GO:0007597 blood coagulation, intrinsic pathway
- GO:0015057 thrombin receptor activity
- GO:0030168 platelet activation
- GO:0042730 fibrinolysis
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