CD357 antibody | rA31B31-05/2E1-7
Mouse anti Human CD357
- Product Type
- Monoclonal Antibody
- Clone
- rA31B31-05/2E1-7
- Isotype
- IgG1
- Specificity
- CD357
Antibody Quality and Performance Guarantee
TZA0139GA
Recombinant Antibodies
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| Mouse anti Human CD357 antibody, clone rA31B31-05/2E1-7, is a recombinant monoclonal antibody that recognizes CD357, also known as Glucocorticoid-induced TNFR related protein (GITR). CD357 is a single-pass type I membrane protein and part of the TNFR superfamily. It is expressed on the surface of regulatory T cells (Tregs) and some activated cells, including natural killer cells, neutrophils and effector T lymphocytes. CD357 triggering on effector T lymphocytes by GITRL generates a positive costimulatory signal, promoting T cell activation and proliferation. CD357 expression is important in the development and activity of Tregs, and activation inhibits their suppressive function. CD357 triggering by its ligand increases resistance to tumors and viral infections. CD357 has a role in inflammation and autoimmune diseases such as rheumatoid arthritis, and is a potential target for immunotherapy of autoimmune diseases. |
- Target Species
- Human
- Product Form
- Purified recombinant IgG containing a SpyTag at the C-terminus of the antibody heavy chain – liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Source
- CHO cells
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Recombinant CD357 Gln26-Glu161 expressed by mammalian cells
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 5μl of the suggested working dilution to label 0.5x106 cells in 100μl. Best practices suggest a 5 min centrifugation at 6,000g prior to sample application.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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| List Price | Your Price | ||||||
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| Description | Mouse IgG1 Negative Control | ||||||
- Synonyms
- GITR
- TNFRSF18
- UniProt
- Q9Y5U5
- Entrez Gene
- TNFRSF18
- GO Terms
- GO:0006915 apoptosis
- GO:0005576 extracellular region
- GO:0005031 tumor necrosis factor receptor activity
- GO:0005887 integral to plasma membrane
- GO:0006916 anti-apoptosis
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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