CD268 / BAFF-R antibody | rA39B39-05/3H8
Mouse anti Human CD268 / BAFF-R
- Product Type
- Monoclonal Antibody
- Clone
- rA39B39-05/3H8
- Isotype
- IgG1
- Specificity
- CD268 / BAFF-R
Antibody Quality and Performance Guarantee
TZA0163GA
Recombinant Antibodies
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| Mouse anti Human CD268 / BAFF-R antibody, clone rA39B39-05/3H8, is a recombinant monoclonal antibody that recognizes CD268, also known as B cell activating factor-receptor (BAFF-R) or Tumor necrosis factor receptor superfamily member 13C. CD268 is an atypical member of the Tumor necrosis factor (TNF) receptor superfamily, containing only a partial cysteine-rich domain for ligand binding and self-assembly. CD268 is almost exclusively expressed on B cells, with expression beginning when immature B cells develop to transitional B cells. CD268 binds the B cell activating factor of the TNF family (BAFF, CD257) and functions as a pro-survival receptor. Ligand binding to CD268 activates several downstream pathways, including canonical and non-canonical NF-κB signaling pathways, regulating protein synthesis and energy metabolism. CD268 can be used as a B cell marker and is expressed on most human peripheral B cell subsets. Homozygous deletion of CD268 in humans results in lack of B cell development, causing B-lymphopenia, agammaglobulinemia and impaired humoral immune response. |
- Target Species
- Human
- Product Form
- Purified recombinant IgG containing a SpyTag at the C-terminus of the antibody heavy chain – liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Source
- CHO cells
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Recombinant CD268 Met1-Leu78 expressed by mammalian cells
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 5μl of the suggested working dilution to label 0.5x106 cells in 100μl. Best practices suggest a 5 min centrifugation at 6,000g prior to sample application.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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| Description | Mouse IgG1 Negative Control | ||||||
- Synonyms
- BAFF-R
- UniProt
- Q96RJ3
- Entrez Gene
- TNFRSF13C
- GO Terms
- GO:0016021 integral to membrane
- GO:0004872 receptor activity
View more products with CD268 / BAFF-R specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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