CD206 antibody | 5C11
Mouse anti Human CD206 antibody, clone 5C11 recognizes human macrophage mannose receptor 1, also known as CD206, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Human mannose receptor, hMR or Macrophage mannose receptor 1-like protein 1. CD206 is a 1438 amino acid ~168-180 kDa single pass type 1 transmembrane glycoprotein and mediator of glycoprotein endocytosis by macrophages. CD206 also acts as a phagocytic receptor for pathogens including bacteria and fungi and acts as a receptor for dengue virus (Miller et al. 2008).
Two isoforms of CD206 produced by alternative splicing have been described. Both isoforms contain the unaltered immunogen sequence used to generate clone 5C11 which is expected therefore to bind both the canonical isoform 1 and the truncated isoform 2 (UniProt : P22897).
Two isoforms of CD206 produced by alternative splicing have been described. Both isoforms contain the unaltered immunogen sequence used to generate clone 5C11 which is expected therefore to bind both the canonical isoform 1 and the truncated isoform 2 (UniProt : P22897).
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Immunogen
- Recombinant protein corresponding to aa 22-131 of human CD206.
- Approx. Protein Concentrations
- Ig concentration 0.5 mg/ml
- Fusion Partners
- Spleen cells from BALB/c mice were fused with cells from the Sp2/0 myeloma cell line.
Storage Information
- Storage
- Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P22897
- Entrez Gene
- MRC1
- GO Terms
- GO:0004872 receptor activity
- GO:0005887 integral to plasma membrane
- GO:0005537 mannose binding
- GO:0006898 receptor-mediated endocytosis
- Regulatory
- For research purposes only
Applications of CD206 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin | 0.1 | 10 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Product Specific References
References for CD206 antibody
-
Komohara, Y. et al. (2016) Contribution of Macrophage Polarization to Metabolic Diseases.
J Atheroscler Thromb. 23 (1): 10-7. -
Zúñiga-Castillo, M. et al. (2018) High density of M2-macrophages in acral lentiginous melanoma compared to superficial spreading melanoma.
Histopathology. 72 (7): 1189-1198.
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