CD206 antibody | 5C11

Mouse anti Human CD206:Preservative Free

Product Type
Monoclonal Antibody
Clone
5C11
Isotype
IgG1
Specificity
CD206

Product Code Applications Pack Size List Price Your Price Qty
MCA5552Z
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
P 0.1 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Mouse anti Human CD206 antibody, clone 5C11 recognizes human macrophage mannose receptor 1, also known as CD206, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Human mannose receptor, hMR or Macrophage mannose receptor 1-like protein 1. CD206 is a 1438 amino acid ~168-180 kDa single pass type 1 transmembrane glycoprotein and mediator of glycoprotein endocytosis by macrophages. CD206 also acts as a phagocytic receptor for pathogens including bacteria and fungi and acts as a receptor for dengue virus (Miller et al. 2008).

Two isoforms of CD206 produced by alternative splicing have been described. Both isoforms contain the unaltered immunogen sequence used to generate clone 5C11 which is expected therefore to bind both the canonical isoform 1 and the truncated isoform 2 (UniProt : P22897).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Immunogen
Recombinant protein corresponding to aa 22-131 of human CD206.
Approx. Protein Concentrations
Ig concentration 0.5 mg/ml
Fusion Partners
Spleen cells from BALB/c mice were fused with cells from the Sp2/0 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 0.1 10 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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References for CD206 antibody

  1. Komohara, Y. et al. (2016) Contribution of Macrophage Polarization to Metabolic Diseases.
    J Atheroscler Thromb. 23 (1): 10-7.
  2. Zúñiga-Castillo, M. et al. (2018) High density of M2-macrophages in acral lentiginous melanoma compared to superficial spreading melanoma.
    Histopathology. 72 (7): 1189-1198.

Synonyms
Mannose Receptor C Type 1
RRID
AB_2144908
UniProt
P22897
Entrez Gene
MRC1
GO Terms
GO:0004872 receptor activity
GO:0005887 integral to plasma membrane
GO:0005537 mannose binding
GO:0006898 receptor-mediated endocytosis
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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