CD1c antibody | L161
Mouse anti Human CD1c
- Product Type
- Monoclonal Antibody
- Clone
- L161
- Isotype
- IgG1
- Specificity
- CD1c
Antibody Quality and Performance Guarantee
* - RPE format is no longer available, clone is still available in an unconjugated format (MCA6129).
Figure B. FITC conjugated Mouse anti Human CD19 antibody, clone LT19 (MCA1940F) and RPE conjugated Mouse anti Human CD1c antibody, clone L161 (MCA6129PE*). All experiments were performed on human peripheral blood lymphocytes blocked with 10% human serum, gated on live single cell lymphocytes.
Data acquired on the ZE5 Cell Analyzer.
* - RPE format is no longer available, clone is still available in an unconjugated format (MCA6129).
IMouse anti Human CD1c antibody, clone L161 (MCA6129) used to label human epidermal cells by immunofluorescence.
Image caption:
Some CD36+ leukocytes coexpress the dendritic cell marker CD1c. Immunofluorescence triple labelling identified CD45+CD36+CD1c+ (arrow) and CD45+CD36-CD1c+ (arrowhead) epidermal cells in first trimester human skin. LC in healthy adult skin express CD1c but never CD36. Scale bars: 50 μm.
From: Schuster C, Mildner M, Mairhofer M, Bauer W, Fiala C, Prior M, Eppel W, Kolbus A, Tschachler E, Stingl G, Elbe-Bürger A.
Human embryonic epidermis contains a diverse Langerhans cell precursor pool.
Development. 2014 Feb;141(4):807-15.
doi: 10.1242/dev.102699.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
IMouse anti Human CD1c antibody, clone L161 (MCA6129) used to label human epidermal cells by immunofluorescence.
Image caption:
Human embryonic epidermis contains leukocytes with distinct phenotypes. (A,C) Immunofluorescence triple labelling identified (C) CD45+CD36+CD1c+ (arrow) and CD45+CD36-CD1c+ (arrowhead) epidermal cells in first trimester human skin. Scale bars: 50 μm.
From: Schuster C, Mildner M, Mairhofer M, Bauer W, Fiala C, Prior M, Eppel W, Kolbus A, Tschachler E, Stingl G, Elbe-Bürger A.
Human embryonic epidermis contains a diverse Langerhans cell precursor pool.
Development. 2014 Feb;141(4):807-15.
doi: 10.1242/dev.102699.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Filter by Application:
F IF Reset| Mouse anti Human CD1c, clone L161, recognizes CD1c. CD1c, along with CD1a and CD1b, belong to group 1 of the CD1 family of glycoproteins. These MHC-like glycoproteins serve as lipid-presenting molecules for a subset of T cells (Porcelli et al. 1989). CD1c is expressed in cortical thymocytes and a subset of B-cells (Delia et al, 1988) as well as myeloid dendritic cells (Collin, McGovern & Haniffa, 2013) |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Immunogen
- Human thymocytes
- Purity
- >95% by SDS PAGE
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- Guaranteed for 12 months from the date of despatch or until the date of expiry, whichever comes first. Please see label for expiry date.
This product is shipped at ambient temperature.
Store at +4°C. DO NOT FREEZE.
This product should be stored undiluted.
Store at +4°C. DO NOT FREEZE.
This product should be stored undiluted.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
||
| Immunohistology - Frozen | |
||
| Immunoprecipitation | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Mouse IgG1 Negative Control | ||||||
References for CD1c antibody
-
Weidler, C. et al. (2004) Low density of CD1+ cells in the synovial tissue of patients with rheumatoid arthritis.
Clin Exp Rheumatol. 22 (4): 433-40. -
Iking-Konert, C. et al. (2001) Transdifferentiation of polymorphonuclear neutrophils: acquisition of CD83 and other functional characteristics of dendritic cells.
J Mol Med (Berl). 79 (8): 464-74. -
Ibrahim, S. & Steinbach, F. (2007) Non-HLDA8 animal homologue section anti-leukocyte mAbs tested for reactivity with equine leukocytes.
Vet Immunol Immunopathol. 119 (1-2): 81-91. -
Schuster, C. et al. (2012) Phenotypic characterization of leukocytes in prenatal human dermis.
J Invest Dermatol. 132 (11): 2581-92. -
Agea, E. et al. (2005) Human CD1-restricted T cell recognition of lipids from pollens.
J Exp Med. 202 (2): 295-308. -
Duangkhae, P. et al. (2018) Interplay between Keratinocytes and Myeloid Cells Drives Dengue Virus Spread in Human Skin.
J Invest Dermatol. 138 (3): 618-26. -
Schuster, C. et al. (2009) HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells.
J Exp Med. 206 (1): 169-81.
Further Reading
-
Delia, D. et al. (1988) CD1c but neither CD1a nor CD1b molecules are expressed on normal, activated, and malignant human B cells: identification of a new B-cell subset.
Blood. 72 (1): 241-7. -
Porcelli, S. et al. (1989) Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes.
Nature. 341 (6241): 447-50. -
Collin, M. et al. (2013) Human dendritic cell subsets.
Immunology. 140 (1): 22-30.
- UniProt
- P29017
- Entrez Gene
- CD1C
- GO Terms
- GO:0005887 integral to plasma membrane
- GO:0006955 immune response
- GO:0010008 endosome membrane
- GO:0019882 antigen processing and presentation
Request a different product with this specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
View all Anti-Human ProductsAlways be the first to know.
When we launch new products and resources to help you achieve more in the lab.
Yes, sign me up
