CD192 antibody | rB2C2-01/1H4
Mouse anti Human CD192
- Product Type
- Monoclonal Antibody
- Clone
- rB2C2-01/1H4
- Isotype
- IgG1
- Specificity
- CD192
Antibody Quality and Performance Guarantee
TZA088GA
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| Mouse anti Human CD192 antibody, clone rB2C2-01/1H4, is a recombinant monoclonal antibody that recognizes CD192, also known as C-C motif chemokine receptor 2 (CCR2). CD192 is a 42 kD transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, which acts as a receptor for the chemokines MCP-1 (monocyte chemoattractant protein 1), MCP-3 and MCP-4. It is mainly expressed on monocytes and macrophages, with lower expression on basophils. Interaction between CD192 and MCP-1 initiates diverse chemotactic responses, particularly in monocytes through an increase in intracellular calcium levels. MCP-1 is involved in the infiltration of monocytes in inflammatory diseases such as rheumatoid arthritis, as well as inflammatory responses against tumors. CD192 acts as a co-receptor with CD4 for HIV1 infection, and variations in CD192 are associated with relative resistance to HIV1. |
- Target Species
- Human
- Product Form
- Purified recombinant IgG containing a SpyTag at the C-terminus of the antibody heavy chain – liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Source
- CHO cells
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Mammalian cells transfected with full length CD192
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 5μl of the suggested working dilution to label 0.5x106 cells in 100μl. Best practices suggest a 5 min centrifugation at 6,000g prior to sample application.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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| List Price | Your Price | ||||||
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| Description | Mouse IgG1 Negative Control | ||||||
- Synonyms
- CCR2
- UniProt
- P41597
- Entrez Gene
- CCR2
- GO Terms
- GO:0005887 integral to plasma membrane
- GO:0005625 soluble fraction
- GO:0005737 cytoplasm
- GO:0006935 chemotaxis
- GO:0006954 inflammatory response
- GO:0006955 immune response
- GO:0006968 cellular defense response
- GO:0007194 negative regulation of adenylate cyclase activity
- GO:0007204 elevation of cytosolic calcium ion concentration
- View More GO Terms
- GO:0007259 JAK-STAT cascade
- GO:0016493 C-C chemokine receptor activity
- GO:0019221 cytokine-mediated signaling pathway
- GO:0031727 CCR2 chemokine receptor binding
- GO:0044419 interspecies interaction between organisms
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