CD164 antibody | 67D2

Mouse anti Human CD164

Product Type
Monoclonal Antibody
Clone
67D2
Isotype
IgG1
Specificity
CD164

Product Code Applications Pack Size List Price Your Price Qty
MCA6124
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
F IC IP WB 0.1 mg loader
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loader
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Mouse anti Human CD164 clone 67D2, recognizes CD164, also known as endolyn, a 160 kDa transmembrne homodimer protein. It is composed of an extracellular region and two O-glycosylated mucin domains (I and II). These two domains are linked by a non-mucin cysteine rich subdomain.

CD164 is a member of the sialmucin family and is expressed by CD34+ hematopoietic progenitor cells, activated basophils, erythroid cells as well as various cancerous cells. A key role of CD164 is its involvement in regulating adhesion, migration and proliferation of hematopoietic progenitor cells (Zannettino et al. 1998).

Elevated expression of CD164 has been observed in patients with Seazy syndrome which is a primary cutaneous T-cell lymphoma and as such, has been suggested as a potential marker of this disease (Guenova et al. 2016).

This clone CD67D2 recognizes the class II epitope which is not sensitive to sialidase, N-glycanase and O-sialglycoprotease of CD164. This clones has been used in flow cytometry to examine CD164 upregulation in CD203c+ activated basophils (Hennersdorf et al. 2005).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
Immunogen
Breast tumor cell line T-47D
Purity
>95% by SDS PAGE
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
Guaranteed for 12 months from the date of despatch or until the date of expiry, whichever comes first. Please see label for expiry date.

Store at +4°C. DO NOT FREEZE.
This product should be stored undiluted.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry
Immunocytochemistry
Immunoprecipitation
Western Blotting
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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References for CD164 antibody

  1. Zannettino, A.C. et al. (1998) The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis.
    Blood. 92 (8): 2613-28.
  2. Guenova, E. et al. (2016) Expression of CD164 on Malignant T cells in Sézary Syndrome.
    Acta Derm Venereol. 96 (4): 464-7.
  3. Hennersdorf, F. et al. (2005) Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation.
    Cell Res. 15 (5): 325-35.

Synonyms
Endolyn
UniProt
Q04900
Entrez Gene
CD164
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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