CD157 antibody | rA47B47-04/2D6-8
Mouse anti Human CD157
- Product Type
- Monoclonal Antibody
- Clone
- rA47B47-04/2D6-8
- Isotype
- IgG1
- Specificity
- CD157
Antibody Quality and Performance Guarantee
TZA0177GA
Recombinant Antibodies
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| Mouse anti Human CD157 antibody, clone rA47B47-04/2D6-8, is a recombinant monoclonal antibody that recognizes CD157, also known as bone marrow stromal cell antigen 1 (BST-1) and ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2. CD157 is a GPI-anchored glycoprotein receptor and ecto-enzyme. In the hematopoietic system, CD157 is prevalently expressed by cells of the myelomonocytic lineage, including macrophages, monocytes and mature neutrophils. Expression is not restricted to the myeloid compartment and CD157 has been detected in cells and tissues of different origins, including the gut and brain. A soluble form of CD157 can be detected in serum and other biological fluids. CD157 binds with high affinity to the heparin binding domains of fibronectin, collagen I, fibrinogen and laminin-1, through which it regulates cell adhesion and migration via integrin mediated signaling. CD157 has both cyclic ADP-ribose hydrolase and ADP-ribosyl cyclase activities, however the functional role of CD157 as an ecto-enzyme is unclear. CD157 is expressed in the majority of Acute myeloid leukemia (AML) patients at the point of diagnosis and is a promising therapeutic target for AML. CD157 has been used as a marker for the diagnosis of paroxysmal nocturnal hemoglobinuria. |
- Target Species
- Human
- Product Form
- Purified recombinant IgG containing a SpyTag at the C-terminus of the antibody heavy chain – liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Source
- CHO cells
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Recombinant human CD157 Gly29-Ala292 expressed by mammalian cells
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 5μl of the suggested working dilution to label 0.5x106 cells in 100μl. Best practices suggest a 5 min centrifugation at 6,000g prior to sample application.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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| Description | Mouse IgG1 Negative Control | ||||||
- Synonyms
- BST-1
- UniProt
- Q10588
- Entrez Gene
- BST1
- GO Terms
- GO:0005886 plasma membrane
- GO:0003953 NAD+ nucleosidase activity
- GO:0005488 binding
- GO:0006959 humoral immune response
- GO:0007275 multicellular organismal development
- GO:0031225 anchored to membrane
- GO:0019898 extrinsic to membrane
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