CD130 antibody | B-T2

Mouse anti Human CD130 antibody, clone B-T2 has been reported to block receptor activity and inhibit IL-6 induced proliferation of XG1 cells and IL-27 mediated proliferation of naive CD4+ T cells(de Groot et al. 2012, Pflanz et al. 2004).
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide - Immunogen
- Natural soluble gp130 receptor.
- Approx. Protein Concentrations
- IgG concentration 1 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c (Iffa Credo) mice were fused with cells of the X63.Ag8.653 mouse myeloma cell line.
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P40189
- Entrez Gene
- IL6ST
- GO Terms
- GO:0002675 positive regulation of acute inflammatory response
- GO:0002821 positive regulation of adaptive immune response
- GO:0005576 extracellular region
- GO:0004897 ciliary neurotrophic factor receptor activity
- GO:0005127 ciliary neurotrophic factor receptor binding
- GO:0005615 extracellular space
- GO:0005896 interleukin-6 receptor complex
- GO:0005900 oncostatin-M receptor complex
- GO:0010575 positive regulation vascular endothelial growth factor production
- GO:0010613 positive regulation of cardiac muscle hypertrophy
- GO:0034097 response to cytokine stimulus
- GO:0042102 positive regulation of T cell proliferation
- GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
- GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
- GO:0042803 protein homodimerization activity
- GO:0045509 interleukin-27 receptor activity
- GO:0045669 positive regulation of osteoblast differentiation
- GO:0045768 positive regulation of anti-apoptosis
- GO:0048861 leukemia inhibitory factor signaling pathway
- GO:0070104 negative regulation of interleukin-6-mediated signaling pathway
- GO:0070106 interleukin-27-mediated signaling pathway
- GO:0070110 ciliary neurotrophic factor receptor complex
- GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
- Regulatory
- For research purposes only
Applications of CD130 antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | |||
Flow Cytometry | 0.2ug/106cells |
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Secondary Antibodies Available
Negative Isotype Controls Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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Product Specific References
References for CD130 antibody
-
Wijdenes, J. et al. (1995) Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies.
Eur J Immunol. 25 (12): 3474-81. -
Cork, B.A.
(2002) Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro.
Mol Hum Reprod. 8: 841-8. -
Zhang, L. et al. (2012) Role of the microenvironment in mantle cell lymphoma: IL-6 is an important survival factor for the tumor cells.
Blood. 120 (18): 3783-92.
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