CD123 antibody | rA26B26-02-4B11
Mouse anti Human CD123
- Product Type
- Monoclonal Antibody
- Clone
- rA26B26-02-4B11
- Isotype
- IgG1
- Specificity
- CD123
Antibody Quality and Performance Guarantee
TZA0132GA
No associated image currently available
| Mouse anti Human CD123 antibody, clone rA26B26-02-4B11, is a recombinant monoclonal antibody that recognizes CD123, also known as the human interleukin-3 (IL-3) receptor alpha chain or IL-3RA. CD123 is the primary low-affinity subunit of the IL-3 receptor, and heterodimerises with the β common subunit (CD131) to form the high affinity IL-3 receptor. CD123 contains two fibronectin III-like domains that bind IL-3, and an N-terminal domain that plays a key role in regulating function and preventing spontaneous receptor dimerization. CD123 is expressed on various hematopoietic cells, including myeloid progenitors, monocytes, basophils and plasmacytoid dendritic cells. CD123 has been found to be upregulated in several hematological malignancies, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), Hodgkin lymphoma, hairy cell leukemia, blastic plasmacytoid dendritic cell neoplasm (BPDCN) and systemic mastocytosis. The differential expression between neoplastic cells and normal precursors has highlighted CD123 as an attractive diagnostic biomarker and potential target for therapy. |
- Target Species
- Human
- Product Form
- Purified recombinant IgG containing a SpyTag at the C-terminus of the antibody heavy chain – liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Source
- CHO cells
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Recombinant CD123 Thr19-Arg305 expressed by mammalian cells
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 5μl of the suggested working dilution to label 0.5x106 cells in 100μl. Best practices suggest a 5 min centrifugation at 6,000g prior to sample application.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Mouse IgG1 Negative Control | ||||||
- UniProt
- P26951
- Entrez Gene
- IL3RA
- GO Terms
- GO:0005886 plasma membrane
- GO:0016021 integral to membrane
- GO:0004912 interleukin-3 receptor activity
View more products with CD123 specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
View all Anti-Human ProductsAlways be the first to know.
When we launch new products and resources to help you achieve more in the lab.
Yes, sign me up