CD11a antibody | 38

Product Code Applications Pack Size List Price Your Price Qty
MCA1848
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F IF IP 0.2 mg loader
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loader
MCA1848GA
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F IF IP 0.1 mg loader
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loader
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Mouse anti Human CD11a antibody, clone 38 recognizes the integrin alpha L subunit, also known as CD11a, leukocyte function-associated molecule 1 alpha chain LFA-1 or integrin alpha-L. CD11a is a ~180 kDa glycoprotein expressed by all human leucocytes. CD11a is involved in cell-cell adhesion processes and binds to ICAM-1, 2 and 3.

Mouse anti Human CD11a antibody, clone 38 inhibits CD11a mediated adhesion of T cells to ICAM-1 (Stewart et al. 1996).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
MCA1848: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
MCA1848GA: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09%Sodium Azide
Carrier Free
Yes
Approx. Protein Concentrations
IgG concentration 1 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1/50 1/100
Immunofluorescence
Immunohistology - Frozen
Immunoprecipitation
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Human Tonsil

Description Product Code Applications Pack Size List Price Your Price Quantity
Human anti Mouse IgG2a:HRP HCA037P E 0.1 mg loader
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loader
Description Human anti Mouse IgG2a:HRP
Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed) STAR117A E WB 0.5 mg loader
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loader
Description Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®488 (Multi Species Adsorbed) STAR117D488GA F IF 0.1 mg loader
List Price Your Price
loader
Description Goat anti Mouse IgG (H/L):DyLight®488 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®550 (Multi Species Adsorbed) STAR117D550 F IF WB 0.1 mg loader
List Price Your Price
loader
Description Goat anti Mouse IgG (H/L):DyLight®550 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®650 (Multi Species Adsorbed) STAR117D650 F IF 0.1 mg loader
List Price Your Price
loader
Description Goat anti Mouse IgG (H/L):DyLight®650 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed) STAR117D680GA F WB 0.1 mg loader
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loader
Description Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed) STAR117D800GA F IF WB 0.1 mg loader
List Price Your Price
loader
Description Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed) STAR117F F 0.5 mg loader
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loader
Description Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):HRP (Multi Species Adsorbed) STAR117P C E WB 0.5 mg loader
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loader
Description Goat anti Mouse IgG (H/L):HRP (Multi Species Adsorbed)
Goat anti Mouse IgG (Fc):FITC STAR120F C F 1 mg loader
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loader
Description Goat anti Mouse IgG (Fc):FITC
Goat anti Mouse IgG (Fc):HRP STAR120P E WB 1 mg loader
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loader
Description Goat anti Mouse IgG (Fc):HRP
Rabbit F(ab')2 anti Mouse IgG:RPE STAR12A F 1 ml loader
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loader
Description Rabbit F(ab')2 anti Mouse IgG:RPE
Rabbit F(ab')2 anti Mouse IgG:HRP (Human Adsorbed) STAR13B C E P RE WB 1 mg loader
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loader
Description Rabbit F(ab')2 anti Mouse IgG:HRP (Human Adsorbed)
Goat anti Mouse IgG:FITC (Rat Adsorbed) STAR70 F 0.5 mg loader
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loader
Description Goat anti Mouse IgG:FITC (Rat Adsorbed)
Goat anti Mouse IgG:RPE (Rat Adsorbed) STAR76 F 1 ml loader
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loader
Description Goat anti Mouse IgG:RPE (Rat Adsorbed)
Goat anti Mouse IgG:HRP (Rat Adsorbed) STAR77 C E P 0.5 mg loader
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loader
Description Goat anti Mouse IgG:HRP (Rat Adsorbed)
Goat anti Mouse IgG/A/M:Alk. Phos. STAR87A C E WB 1 mg loader
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loader
Description Goat anti Mouse IgG/A/M:Alk. Phos.
Goat anti Mouse IgG/A/M:HRP (Human Adsorbed) STAR87P E 1 mg loader
List Price Your Price
loader
Description Goat anti Mouse IgG/A/M:HRP (Human Adsorbed)
Rabbit F(ab')2 anti Mouse IgG:Dylight®800 STAR8D800GA F IF WB 0.1 mg loader
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loader
Description Rabbit F(ab')2 anti Mouse IgG:Dylight®800
Rabbit F(ab')2 anti Mouse IgG:FITC STAR9B F 1 mg loader
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loader
Description Rabbit F(ab')2 anti Mouse IgG:FITC

Description Product Code Applications Pack Size List Price Your Price Quantity
Mouse IgG2a Negative Control MCA929 F 100 Tests loader
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loader
Description Mouse IgG2a Negative Control

References for CD11a antibody

  1. Dransfield, I. & Hogg, N. (1989) Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits.
    EMBO J. 8 (12): 3759-65.
  2. Berg, L.P. et al. (2002) Functional consequences of noncognate interactions between CD4+ memory T lymphocytes and the endothelium.
    J Immunol. 168 (7): 3227-34.
  3. Foster, G.R. et al. (2004) IFN-alpha subtypes differentially affect human T cell motility.
    J Immunol. 173: 1663-70.
  4. Evans, B.J. et al. (2006) Shedding of lymphocyte function-associated antigen-1 (LFA-1) in a human inflammatory response.
    Blood. 107: 3593-9.
  5. Suchard, S.J. et al. (2010) An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.
    J Immunol. 184: 3917-26.
  6. Porter, J.C. and Hall, A. (2009) Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.
    FASEB J. 23: 492-502.
  7. Daehn, I.S. (2010) T-lymphocyte-induced, fas-mediated apoptosis is associated with early keratinocyte differentiation.
    Exp Dermatol. 19: 372-80.
  8. Dominical, V.M. et al. (2014) Prominent role of platelets in the formation of circulating neutrophil-red cell heterocellular aggregates in sickle cell anemia.
    Haematologica. 99 (11): e214-7.
  9. View The Latest Product References
  10. Stax, A.M. et al. (2017) Autoreactivity to Sulfatide by Human Invariant NKT Cells.
    J Immunol. 199 (1): 97-106.

Flow Cytometry

Functional Assays

Immunofluorescence

Synonyms
Integrin Alpha L Chain
LFA-1
RRID
AB_322231
UniProt
P20701
Entrez Gene
ITGAL
GO Terms
GO:0007157 heterophilic cell-cell adhesion
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0007596 blood coagulation
GO:0050839 cell adhesion molecule binding
GO:0004872 receptor activity
GO:0008305 integrin complex
GO:0006954 inflammatory response
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0050776 regulation of immune response
GO:0050900 leukocyte migration
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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