CD11a antibody | 38
Mouse anti Human CD11a
- Product Type
- Monoclonal Antibody
- Clone
- 38
- Isotype
- IgG2a
- Specificity
- CD11a
Antibody Quality and Performance Guarantee
| Mouse anti Human CD11a antibody, clone 38 recognizes the integrin alpha L subunit, also known as CD11a, leukocyte function-associated molecule 1 alpha chain LFA-1 or integrin alpha-L. CD11a is a ~180 kDa glycoprotein expressed by all human leucocytes. CD11a is involved in cell-cell adhesion processes and binds to ICAM-1, 2 and 3. Mouse anti Human CD11a antibody, clone 38 inhibits CD11a mediated adhesion of T cells to ICAM-1 ( |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
- Carrier Free
- Yes
- Approx. Protein Concentrations
- IgG concentration 1 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
1/50 | 1/100 |
| Immunofluorescence | |
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| Immunohistology - Frozen | |
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| Immunoprecipitation | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Human tonsil
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG2a Negative Control | MCA929 | F | 100 Tests |
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Log in | ||
| List Price | Your Price | ||||||
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| Description | Mouse IgG2a Negative Control | ||||||
References for CD11a antibody
-
Dransfield, I. & Hogg, N. (1989) Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits.
EMBO J. 8 (12): 3759-65. -
Berg, L.P. et al. (2002) Functional consequences of noncognate interactions between CD4+ memory T lymphocytes and the endothelium.
J Immunol. 168 (7): 3227-34. -
Foster, G.R. et al. (2004) IFN-alpha subtypes differentially affect human T cell motility.
J Immunol. 173: 1663-70. -
Evans, B.J. et al. (2006) Shedding of lymphocyte function-associated antigen-1 (LFA-1) in a human inflammatory response.
Blood. 107: 3593-9. -
Suchard, S.J. et al. (2010) An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.
J Immunol. 184: 3917-26. -
Porter, J.C. and Hall, A. (2009) Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.
FASEB J. 23: 492-502. -
Daehn, I.S. (2010) T-lymphocyte-induced, fas-mediated apoptosis is associated with early keratinocyte differentiation.
Exp Dermatol. 19: 372-80. -
Dominical, V.M. et al. (2014) Prominent role of platelets in the formation of circulating neutrophil-red cell heterocellular aggregates in sickle cell anemia.
Haematologica. 99 (11): e214-7.
View The Latest Product References
-
Stax, A.M. et al. (2017) Autoreactivity to Sulfatide by Human Invariant NKT Cells.
J Immunol. 199 (1): 97-106.
- Synonyms
- Integrin Alpha L Chain
- LFA-1
- RRID
- AB_322231
- UniProt
- P20701
- Entrez Gene
- ITGAL
- GO Terms
- GO:0007157 heterophilic cell-cell adhesion
- GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
- GO:0007596 blood coagulation
- GO:0050839 cell adhesion molecule binding
- GO:0004872 receptor activity
- GO:0008305 integrin complex
- GO:0006954 inflammatory response
- GO:0007159 leukocyte cell-cell adhesion
- GO:0007229 integrin-mediated signaling pathway
- View More GO Terms
- GO:0050776 regulation of immune response
- GO:0050900 leukocyte migration
MCA1848GA
169289
1711
MCA1848
1603
167502
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