CD102 antibody | B-T1
Mouse anti Human CD102
- Product Type
- Monoclonal Antibody
|Mouse anti Human CD102 antibody, clone B-T1 recognizes human Intercellular adhesion molecule 2, also known as CD102 or ICAM-2. CD102 is a 275 amino acid ~55-65 kDa single pass type-1 transmembrane glycoprotein containing two Ig-like C2-type domains.
Mouse anti Human CD102 antibody, clone B-T1 inhibits cell adhesion (Xie et al. 1995)and T cell activation and also recognizes soluble ICAM-2.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by ion exchange chromatography from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% sodium azide (NaN3)
- ICAM-2 transfected CHO cells.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunized BALB/c (Iffa Credo) mice were fused with cells of the X63/Ag.8653 mouse myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 106 cells in 100μl.
References for CD102 antibody
Xie, J. et al. (1995) Intercellular adhesion molecule-2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domain.
J Immunol. 155 (7): 3619-28.
Jolly, C. et al. (2007) Adhesion molecule interactions facilitate human immunodeficiency virus type 1-induced virological synapse formation between T cells.
J Virol. 81 (24): 13916-21.
Huang, M.T. et al. (2005) Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis.
Birdsey, G.M. et al. (2008) Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin.
Blood. 111: 3498-506.
Carreno, M.P. et al. (2002) Binding of LFA-1 (CD11a) to intercellular adhesion molecule 3 (ICAM-3; CD50) and ICAM-2 (CD102) triggers transmigration of human immunodeficiency virus type 1-infected monocytes through mucosal epithelial cells.
J Virol. 76: 32-40.
Starke, R.D. et al. (2011) Endothelial von Willebrand factor regulates angiogenesis.
Blood. 117: 1071-80.
Ishido, S. et al. (2000) Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein.
Immunity. 13: 365-74.
Fricke. B. et al. (2005) Stomatin is mis-trafficked in the erythrocytes of overhydrated hereditary stomatocytosis, and is absent from normal primitive yolk sac-derived erythrocytes.
Br J Haematol.131: 265-77.
View The Latest Product References
Garbe, Y. et al. (2011) Semiallogenic fusions of MSI(+) tumor cells and activated B cells induce MSI-specific T cell responses.
BMC Cancer. 11: 410.
McLaughlin, F. et al. (1998) Tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta down-regulate intercellular adhesion molecule (ICAM)-2 expression on the endothelium.
Cell Adhes Commun. 6 (5): 381-400.
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