Mouse anti Human CD102 antibody, clone B-T1
recognizes human Intercellular adhesion molecule 2, also known as CD102 or ICAM-2. CD102 is a 275 amino acid ~55-65 kDa single pass type-1 transmembrane glycoprotein containing two Ig-like C2-type
Mouse anti Human CD102 antibody, clone B-T1 inhibits cell adhesion (Xie et al. 1995
)and T cell activation and also recognizes soluble ICAM-2.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by ion exchange chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- ICAM-2 transfected CHO cells.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunized BALB/c (Iffa Credo) mice were fused with cells of the X63/Ag.8653 mouse myeloma cell line.
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
integral to plasma membrane
regulation of immune response
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD102 antibody
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
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Secondary Antibodies Available
Negative Isotype Controls Available
Application Based External Images
Product Specific References
References for CD102 antibody
Xie, J. et al. (1995) Intercellular adhesion molecule-2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domain.
J Immunol. 155 (7): 3619-28.
Jolly, C. et al. (2007) Adhesion molecule interactions facilitate human immunodeficiency virus type 1-induced virological synapse formation between T cells.
J Virol. 81 (24): 13916-21.
Huang, M.T. et al. (2005) Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis.
Birdsey, G.M. et al. (2008) Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin.
Blood. 111: 3498-506.
Carreno, M.P. et al. (2002) Binding of LFA-1 (CD11a) to intercellular adhesion molecule 3 (ICAM-3; CD50) and ICAM-2 (CD102) triggers transmigration of human immunodeficiency virus type 1-infected monocytes through mucosal epithelial cells.
J Virol. 76: 32-40.
Starke, R.D. et al. (2011) Endothelial von Willebrand factor regulates angiogenesis.
Blood. 117: 1071-80.
Ishido, S. et al. (2000) Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein.
Immunity. 13: 365-74.
Fricke. B. et al. (2005) Stomatin is mis-trafficked in the erythrocytes of overhydrated hereditary stomatocytosis, and is absent from normal primitive yolk sac-derived erythrocytes.
Br J Haematol.131: 265-77.
Garbe, Y. et al. (2011) Semiallogenic fusions of MSI(+) tumor cells and activated B cells induce MSI-specific T cell responses.
BMC Cancer. 11: 410.
McLaughlin, F. et al. (1998) Tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta down-regulate intercellular adhesion molecule (ICAM)-2 expression on the endothelium.
Cell Adhes Commun. 6 (5): 381-400.
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