CD101 antibody | BB27
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|Mouse anti Human CD101 antibody, clone BB27 recognizes human CD101, also known as Immunoglobulin superfamily member 2 (IgSF2), . Cell surface glycoprotein V7, Glu-Trp-Ile EWI motif-containing protein 101 or EWI-101. CD101 is a 1021 amino acid, includinng a 20 amino acid signal peptide, ~140 kDa single pass type I homodimeric cell surface glycoprotein expressed primarily by monocytes, granulocytes, dendritic cells and activated T lymphocytes.
CD101 plays a major role in the activation of T cells by skin dendritic cells. Mouse anti Human CD101 antibody, clone BB27 has been reported to inhibit allogeneic T-cell responses (Bagot et al. 1997).
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
- Carrier Free
- Human thymic clone B12.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 106 cells in 100μl
Gouttefangeas, C. et al. (1994) Differential proliferative responses in subsets of human CD28+ cells delineated by BB27 mAb.
Int Immunol. 6 (3): 423-30.
References for CD101 antibody
Bagot, M. et al. (1997) CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation.
Tissue Antigens. 50 (5): 439-48.
Jovanovic, D.V. et al. (2011) CD101 expression and function in normal and rheumatoid arthritis-affected human T cells and monocytes/macrophages.
J Rheumatol. 38: 419-28.
Ohradanova-Repic, A. et al. (2016) Differentiation of human monocytes and derived subsets of macrophages and dendritic cells by the HLDA10 monoclonal antibody panel.
Clin Transl Immunology. 5 (1): e55.
Okuno, M. et al. (2017) Nucleotide substitutions in CD101, the human homolog of a diabetes susceptibility gene in non-obese diabetic mouse, in patients with type 1 diabetes.
J Diabetes Investig. 8 (3): 286-94.
Grassi, F. et al. (1998) Monocyte-derived dendritic cells have a phenotype comparable to that of dermal dendritic cells and display ultrastructural granules distinct from Birbeck granules.
J Leukoc Biol. 64 (4): 484-93.
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