Mouse anti Human CCL27 antibody, clone A01-2H4,
recognizes C-C motif chemokine 27, also known as CTACK, ESkine, ILC, and SCYA27. CCL27 is a C-C motif chemokine. CCR10 is the only known receptor for CCL27, and is expressed in normal skin (Mao et al. 2018
). CCL27 is able to attract a subset of memory / effector T cells from peripheral blood to specific locations on the skin (Wang et al. 2018
). CCL27 plays a role in T cell mediated skin inflammation, and high levels have been found in patients with psoraisis and atopic dermatitis. Upregulation of CCL27 has been identified in patients with myeloma, and is correlated with poor overall survival (Thangavadivel et al. 2016
). CCL27 is secreted by primary tumor cells with high metastatic potential and is able to attract lymphatic endothelial cells, a crucial process during lymphangiogenesis (Karnezis et al. 2019
This purified Mouse anti Human CCL27 antibody, clone A01-2H4 (MCA6184GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CCL27 antibody, clone B05-10H9 (MCA6185B
) as the detection antibody.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CCL27 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.