CCL24 antibody | C05-2B5

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Mouse anti Human CCL24

Product Type
Monoclonal Antibody
Clone
C05-2B5
Isotype
IgG1
Product Code Applications Pack Size List Price Quantity
MCA6182GA
Datasheet
E
SDS
0.1 mg loader

Mouse anti Human CCL24 antibody, clone C05-2B5recognizes C-C motif chemokine 24, also known as Eotaxin-2, CK-beta-6, and MPIF-2. CCL24 is a chemokine which is induced in macophages and promotes recruitment and activation of immune cells including eosinophils, basophils, and Th2 cells by interacting with the CCR3 receptor. Therefore, CCL24 expression increases during inflammatory disease and allergic reaction, and CCL24 has been shown to perpetuate allergic reaction (Cho et al. 2016). CCL24 is involved with proinflammatory and profibrotic reactions, particularly fibrosis of the skin and lungs (Mor et al. 2019). Furthermore, CCL24 plays a role in intrahepatic fibrosis and liver damage (Segal-Salto et al. 2020). Elevated CCL24 has been associated with primary colorectal and liver metastatic tumors (Cheng et al. 2017).

The purified Mouse anti Human CCL24 antibody, clone C05-2B5 (MCA6182GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CCL24 antibody, clone B01-5E2 (MCA6183B) as the detection antibody.

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Carrier Free
Yes
Immunogen
E. coli derived recombinant human full length CCL24 (Val27-Ala104)
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0

Storage Information

Storage
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Guarantee
12 months from date of despatch

More Information

UniProt
O00175
Entrez Gene
CCL24
GO Terms
GO:0001938 positive regulation of endothelial cell proliferation
GO:0007165 signal transduction
GO:0005615 extracellular space
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007267 cell-cell signaling
GO:0008009 chemokine activity
GO:0030335 positive regulation of cell migration
GO:0030838 positive regulation of actin filament polymerization
GO:0032855 positive regulation of Rac GTPase activity
Regulatory
For research purposes only

Applications of CCL24 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1.0 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed) STAR117A E WB 0.5 mg loader
Goat anti Mouse IgG (H/L):DyLight®488 (Multi Species Adsorbed) STAR117D488GA F IF 0.1 mg loader
Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed) STAR117D680GA F WB 0.1 mg loader
Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed) STAR117D800GA F IF WB 0.1 mg loader
Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed) STAR117F F 0.5 mg loader
Goat anti Mouse IgG (H/L):HRP (Multi Species Adsorbed) STAR117P C E WB 0.5 mg loader
Goat anti Mouse IgG (Fc):FITC STAR120F C F 1 mg loader
Goat anti Mouse IgG (Fc):HRP STAR120P E WB 1 mg loader
Rabbit F(ab')2 anti Mouse IgG:RPE STAR12A F 1 ml loader
Rabbit F(ab')2 anti Mouse IgG:HRP (Human Adsorbed) STAR13B C E P RE WB 1 mg loader
Goat anti Mouse IgG:FITC (Rat Adsorbed) STAR70 F 0.5 mg loader
Goat anti Mouse IgG:RPE (Rat Adsorbed) STAR76 F 1 ml loader
Goat anti Mouse IgG:HRP (Rat Adsorbed) STAR77 C E P 0.5 mg loader
Goat anti Mouse IgG/A/M:Alk. Phos. STAR87A C E WB 1 mg loader
Goat anti Mouse IgG/A/M:HRP (Human Adsorbed) STAR87P E 1 mg loader
Rabbit F(ab')2 anti Mouse IgG:Dylight®800 STAR8D800GA F IF WB 0.1 mg loader
Rabbit F(ab')2 anti Mouse IgG:FITC STAR9B F 1 mg loader

Useful Reagents Available

Description Product Code Applications Pack Size List Price Quantity
Mouse anti Human CCL24:Biotin MCA6183B E 0.1 mg loader
Recombinant Human CCL24 PHP296 E 10 µg loader

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