C8 antibody | 056B-373
|Mouse anti Human C8 antibody, clone 056B-373 recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane.
Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Purified human C8
- Approx. Protein Concentrations
- Current, batch-specific concentration 1.08 mg/ml
- For research purposes only
- Guaranteed until date of expiry. Please see product label.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- Histology Positive Control Tissue
- Kidney from post streptoccal glomerulonephritis patients
References for C8 antibody
Rosa, D.D. et al. (2004) Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis--case report and literature review.
Braz J Infect Dis. 8 (4): 328-30.
Schreck, S.F. et al. (2000) Human complement protein C8 gamma.
Biochim Biophys Acta. 1482 (1-2): 199-208.
- Complement Component 8
- Entrez Gene
- GO Terms
- GO:0005579 membrane attack complex
- GO:0005615 extracellular space
- GO:0006957 complement activation, alternative pathway
- GO:0006958 complement activation, classical pathway
- GO:0019835 cytolysis
- GO:0005576 extracellular region
- GO:0005215 transporter activity
- GO:0019841 retinol binding
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