C4bp antibody | 051-198.6.3 (10-07)

Mouse anti Human C4bp

Product Type
Monoclonal Antibody
Clone
051-198.6.3 (10-07)
Isotype
IgG2b
Specificity
C4bp

Product Code Applications Pack Size List Price Your Price Qty
MCA2609
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E 0.1 mg
List Price Your Price
Search for Batch Specific Datasheets

Mouse anti human C4bp monoclonal antibody, clone 051-198.6.3 (10-07), recognizes complement component 4 binding protein (C4bp). There are three variants of C4bp, composed of alpha and beta chains. The predominant form is a 570 kDa complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain.

C4bp regulates the activation of the classical complement pathway. It is a cofactor to the C3b/C4b inactivator, crucial to the proteolytic cleavage of C4b and important in cleavage of C3b. C4bp also regulates the C4bC2a complex (C3 convertase), accelerating its degradation by dissociating the complement fragment C2a.

Both the C4bp alpha and beta chains interact with anticoagulant protein S and C4bp alpha binds protein S. C4bp is expressed in the blood serum.

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from ascites
Buffer Solution
Borate buffered saline
Preservative Stabilisers
0.1% Sodium Azide (NaN3)
Immunogen
Native human C4 binding protein.
Approx. Protein Concentrations
IgG concentration 1.04 mg/ml
Regulatory
For research purposes only
Guarantee
Guaranteed until date of expiry. Please see product label.

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

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Description Goat anti Mouse IgG (H/L):DyLight®650 (Multi Species Adsorbed)
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References for C4bp antibody

  1. Huang, S. et al. (2016) Reciprocal relationship between contact and complement system activation on artificial polymers exposed to whole human blood
    Biomaterials. 77: 111-9.

Further Reading

  1. Blom, A.M. et al. (2004) Functions of human complement inhibitor C4b-binding protein in relation to its structure.
    Arch Immunol Ther Exp (Warsz). 52 (2): 83-95.

Synonyms
Complement Component 4BP
RRID
AB_2066894
UniProt
P04003
Entrez Gene
C4BPA
GO Terms
GO:0005515 protein binding
GO:0005576 extracellular region
GO:0006958 complement activation, classical pathway
GO:0045087 innate immune response
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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