C4bp antibody | 051-198.6.3 (10-07)
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Mouse anti Human C4bp
- Product Type
- Monoclonal Antibody
- Clone
- 051-198.6.3 (10-07)
- Isotype
- IgG2b
- Specificity
- C4bp
Antibody Quality and Performance Guarantee
| Mouse anti human C4bp monoclonal antibody, clone 051-198.6.3 (10-07), recognizes complement component 4 binding protein (C4bp). There are three variants of C4bp, composed of alpha and beta chains. The predominant form is a 570 kDa complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. C4bp regulates the activation of the classical complement pathway. It is a cofactor to the C3b/C4b inactivator, crucial to the proteolytic cleavage of C4b and important in cleavage of C3b. C4bp also regulates the C4bC2a complex (C3 convertase), accelerating its degradation by dissociating the complement fragment C2a. Both the C4bp alpha and beta chains interact with anticoagulant protein S and C4bp alpha binds protein S. C4bp is expressed in the blood serum. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Immunogen
- Native human C4 binding protein.
- Approx. Protein Concentrations
- IgG concentration 1.145 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- Guaranteed until date of expiry. Please see product label.
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
References for C4bp antibody
-
Huang, S. et al. (2016) Reciprocal relationship between contact and complement system activation on artificial polymers exposed to whole human blood
Biomaterials. 77: 111-9.
Further Reading
-
Blom, A.M. et al. (2004) Functions of human complement inhibitor C4b-binding protein in relation to its structure.
Arch Immunol Ther Exp (Warsz). 52 (2): 83-95.
- Synonyms
- Complement Component 4BP
- RRID
- AB_2066894
- UniProt
- P04003
- Entrez Gene
- C4BPA
- GO Terms
- GO:0005515 protein binding
- GO:0005576 extracellular region
- GO:0006958 complement activation, classical pathway
- GO:0045087 innate immune response
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