C3c antibody | 013E-498.2.3 (10-02A)

C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Immunogen
- Human C3 from normal serum, highly purified by chromatography.
- Approx. Protein Concentrations
- Please see label for concentration
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- Guaranteed until date of expiry. Please see product label.
More Information
- UniProt
- P01024
- Entrez Gene
- C3
- GO Terms
- GO:0005102 receptor binding
- GO:0004866 endopeptidase inhibitor activity
- GO:0005615 extracellular space
- GO:0006954 inflammatory response
- GO:0006957 complement activation, alternative pathway
- GO:0006958 complement activation, classical pathway
- GO:0007186 G-protein coupled receptor protein signaling pathway
- GO:0010575 positive regulation vascular endothelial growth factor production
- Regulatory
- For research purposes only
Applications of C3c antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA 1 | |||
Flow Cytometry | |||
Immunohistology - Frozen | |||
Western Blotting |
- 1Clone 10-02A binds both C3c and C3 and so is not suitable for all ELISA applications.
- Histology Positive Control Tissue
- Kidney from post streptococal glomerulonephritis patients.
Secondary Antibodies Available
Negative Isotype Controls Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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Product Specific References
References for C3c antibody
-
Sica, M. et al. (2017) Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes.
J Hematol Oncol. 10 (1): 126.
Further Reading
-
Janssen, B.J. et al. (2005) Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature. 437 (7058): 505-11.
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