C3/C3b antibody | 755
|Mouse anti Human C3/C3b antibody, clone 755, recognizes an epitope within the C-terminal 360 amino acids on the alpha chain of C3 and recognizes both C3b and C3. C3 is a 185 kDa glycoprotein consisting of an alpha and beta chain and is the key component of the complement activation pathways. It is also the most abundant complement protein within serum, with levels of ~1.3 mg/ml (Sim et al. 1981).
There are 3 activation pathways within the complement system; the classical, lectin and alternative pathways. All three pathways converge on C3, resulting in its cleavage to anaphylatoxin C3a and opsonin C3b. C3b targets microbial cell surface receptors, marking them for phagocytosis by macrophages (Fournis et al. 2019). C3b and its degradation products also play a role in the removal of complement-coated apoptotic and necrotic cells (Xu et al. 2008). In what is considered to be a consequence of this functionality, patients with C3 deficiencies are subject to recurrent bacterial infections (Tedesco 2008).
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Native human C3
- Approx. Protein Concentrations
- IgG concentration 0.1 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen||1/50|
|Immunohistology - Paraffin||1/200|
- Entrez Gene
- GO Terms
- GO:0005102 receptor binding
- GO:0004866 endopeptidase inhibitor activity
- GO:0005615 extracellular space
- GO:0006954 inflammatory response
- GO:0006957 complement activation, alternative pathway
- GO:0006958 complement activation, classical pathway
- GO:0007186 G-protein coupled receptor protein signaling pathway
- GO:0010575 positive regulation vascular endothelial growth factor production
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