C1s antibody | M81
|Mouse anti Human C1s antibody, clone M81, recognizes human C1s, a subcomponent of complement component 1 (C1). This antibody recognizes an epitope around the binding site of C1s, in the IV domain and/or the V of the gamma domain and detects active and inactive C1s.
C1 is a large inactive plasma complex containing one subunit of C1q, 2 subunits of C1r and 2 C1s subunits, which are non-covalently bound together. C1 is the first responder in the classical activation pathway in the complement cascade (Noris & Remuzzi 2013). The classical pathway is initiated when the C1q subunit comes into close proximity of the Fc regions of immunoglobulin’s that have bound close together to an antigen fixed on the surface of a pathogen. This binding by C1q results in the auto-activation of C1r which subsequently releases active C1s units. The newly released active C1s cleaves C4 and C2 creating C4b and C2a which then help to generate C3 convertase to continue the cascade (Janeway et al. 2001).
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Approx. Protein Concentrations
- IgG concentration 0.1 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
|Immunohistology - Paraffin|
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