Beta-2 Adrenergic Receptor antibody | R11E1
Mouse anti Human beta-2 Adrenergic Receptor antibody, clone R11E1 recognizes human beta 2 adrenergic receptor (beta2AR), a member of the G protein-coupled receptor superfamily. Beta1 and Beta2 adrenergic receptors are functionally similar but have different affinities for the ligands adrenaline and noraderenaline. B2A receptors co-exist with the B1A receptors but one subtype usually predominates. B2A receptors have a higher affinity for adrenaline and mediate the relaxation of smooth muscle including bronchus, intestine & uterus. They are located presynaptically in the nerves, where they facilitate neurotransmitter release in the brain and regulate a variety of physiological processes. Ligand binding of the B2A receptor leads to the activation of adenylyl cyclase through interaction with the GTP-binding protein Gs.
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Mouse Rat
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Purified human Beta-2 adrenergic receptor.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Fusion Partners
- Cells from immunised Balb/c mice were fused with cells of the X63Ag8.653 myeloma cell line.
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- Shelf Life
- 18 months from date of despatch.
- P07550 Related reagents
- Entrez Gene
- ADRB2 Related reagents
- For research purposes only
Applications of Beta-2 Adrenergic Receptor antibody
|Application Name||Verified||Min Dilution||Max Dilution|
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Negative Isotype Controls Available
|Description||Product Code||Pack Size||Applications||List Price||Quantity|
|Mouse IgG1 Negative Control||MCA928||100 Tests||F|
Product Specific References
Frielle, T. et al. (1989) Properties of the beta1- and beta2-adrenergic receptor subtypes revealed by molecular cloning.
Clin Chem 35:721-725