Beta-2 Adrenergic Receptor antibody | R11E1
Mouse anti Human beta-2 Adrenergic Receptor antibody, clone R11E1 (MCA2784) used to evaluate the number of ADRB2 expressing T lymphocytes by flow cytometry.
Image caption:
Expression of the ADRB2 on the surface of CD3+ lymphocytes. Data are shown as the percentage of positive cells for 5 HV and 10 BI patients. Top and down whiskers represent the 25th percentile, the median, and the 75th percentile (**p < 0.01, ***p < 0.001; statistical analysis, Mann-Whitney test)
From: Patinec A, Rocher J, Vourc'h M, Roquilly A, Asehnoune K, Le Pendu J.
Alterations of the iNKT cell compartment in brain-injured patients.
Crit Care. 2019 Jun 28;23(1):234.
doi: 10.1186/s13054-019-2518-2.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Filter by Application:
F ResetMouse anti Human Beta-2 Adrenergic Receptor
- Product Type
- Monoclonal Antibody
- Clone
- R11E1
- Isotype
- IgG1
- Specificity
- Beta-2 Adrenergic Receptor
Antibody Quality and Performance Guarantee
| Mouse anti Human beta-2 Adrenergic Receptor antibody, clone R11E1 recognizes human beta 2 adrenergic receptor (beta2AR), a member of the G protein-coupled receptor superfamily. Beta1 and Beta2 adrenergic receptors are functionally similar but have different affinities for the ligands adrenaline and noraderenaline. B2A receptors co-exist with the B1A receptors but one subtype usually predominates. B2A receptors have a higher affinity for adrenaline and mediate the relaxation of smooth muscle including bronchus, intestine & uterus. They are located presynaptically in the nerves, where they facilitate neurotransmitter release in the brain and regulate a variety of physiological processes. Ligand binding of the B2A receptor leads to the activation of adenylyl cyclase through interaction with the GTP-binding protein Gs. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- Purified human Beta-2 adrenergic receptor.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Fusion Partners
- Cells from immunised Balb/c mice were fused with cells of the X63Ag8.653 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
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| Flow Cytometry | |
Neat | 1/25 |
| Immunofluorescence | |
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| Immunohistology - Paraffin | |
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| Immunoprecipitation | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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| List Price | Your Price | ||||||
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| Description | Mouse IgG1 Negative Control | ||||||
References for Beta-2 Adrenergic Receptor antibody
-
Patinec, A. et al. (2019) Alterations of the iNKT cell compartment in brain-injured patients.
Crit Care. 23 (1): 234.
Further Reading
-
Frielle, T. et al. (1989) Properties of the beta 1- and beta 2-adrenergic receptor subtypes revealed by molecular cloning.
Clin Chem. 35 (5): 721-5.
- RRID
- AB_10848357
- UniProt
- P07550
- Entrez Gene
- ADRB2
MCA2784GA
153045
MCA2784
155270
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