IgGb antibody | CVS39
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|Mouse anti Horse IgGb antibody, clone CVS39 recognizes equine IgGb, also known as equine IgG4/7 (Keggan et al. 2013), and shows no significant binding to other IgG subclasses. Equine IgGb is an immunologlobulin with a molecular weight (MW) of approximately 160kDa, the MW of the light chain being 27kDa, common to all equine IgG subclasses, while the heavy chain has a MW of 53kDa, specific to IgGb (Sheoran et al. 1998). Equine IgGb has been demonstrated to be involved in long lasting immunity following respiratory-related viral infections such as Equine Herpes virus Type 4 (EHV-4) (Mizukoshi et al. 2002) and Equine Influenza (Soboll et al. 2003).
In addition to Mouse anti Horse IgGb, clone CVS39, Bio-Rad also offer a range of other monoclonal and polyclonal antibodies that are specific to equine immunoglobulin classes and subclasses.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Purified equine IgGb.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised Balb/c mice were fused with cells of the mouse X63-Ag8.653 myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
References for IgGb antibody
Sheoran, A.S. et al. (1998) Monoclonal antibodies to subclass-specific antigenic determinants on equine immunoglobulin gamma chains and their characterization.
Vet Immunol Immunopathol. 62 (2): 153-65.
Lewis, M.J. et al. (2008) The different effector function capabilities of the seven equine IgG subclasses have implications for vaccine strategies.
Mol Immunol. 45 (3): 818-27.
Keggan, A. et al (2013) Production of seven monoclonal equine immunoglobulins isotyped by multiplex analysis
Vet Immunol Immunopathol.153(3-4):187-93
Palm, A.E. et al. (2016) Secretory immunoglobulin A and immunoglobulin G in horse saliva.
Vet Immunol Immunopathol. 180: 59-65.
Mizukoski, F. et al (2002) IgG antibody subclass response against equine herpesvirus type 4 in horses.
Vet Immunol Immunopathol. 88(1-2):97-101.
Soboll, G. et al (2003) Regional antibody and cellular immune responses to equine influenza virus infection, and particle mediated DNA vaccination.
Vet Immunol Immunopathol. 94(1-2):47-62.
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