IgG: Immunoglobulin G Class

Author: Misha Rahman, Ph.D.

Human IgG (immunoglobulin G) is expressed on the surface of mature B cells and is the most prevalent Ig in serum and the major Ig in extravascular spaces. IgG1, IgG2 and IgG3 are complement activators, with IgG3 being the strongest.

Human immunoglobulin subclasses IgG1 and IgG3 tend to strongly bind fragment crystallization (Fc) receptors, whereas subclasses IgG2 and IgG4 bind weakly. IgG is also the only human immunoglobulin to pass from mother to fetus to transfer immunity.

It should be noted, the human immunoglobulin subclass IgG2 does cross the placenta, but it does so weakly.

IgG Immunoglobulin Class G: IgG

Heavy chain

γ

Light chain

κ or λ

Molecular formula

γ2κ2 or γ2λ2

Valency

2

Structure

Monomer

Abundance in serum (in relation to total immunoglobulins present)

80%

Carbohydrate content

3%

Concentration in serum

10 - 16 mg/ml

IgG subclasses

IgG1

IgG2

IgG3

IgG4

Heavy chain subclasses

γ1

γ2

γ3

γ4

Heavy chain MW (kDa)

50

50

60

50

Light chain MW (kDa)

23

23

23

23

Total MW (kDa)

150

150

170

150

Distribution

Intravascular and extravascular

Function

Secondary response antibody


Antibodies for IgG

Bio-Rad offers a range of human immunoglobulin antibodies for the IgG isotype. In addition to human, we also offer IgG antibodies for a wide range of other target species. Below you will find a list of all of our IgG antibodies. Use the buttons/filters to identify the antibody that fits your exact requirements.

IgG

IgG1

IgG2

IgG3

IgG4

Human

Mouse

Rabbit

Rat

Goat

IgG (Immunoglobulin G) Antibodies

    DescriptionSpecificityTargetFormatHostIsotypeClone Applications Citations Product Type Code

    Further Reading

    For a full overview of Immunoglobulin classes please visit our Immunoglobulins Classes / Sub-classes page. Alternatively you can view the following individual types:

    Learn about Secondary Antibody Specific Binding Locations.