IFN Alpha antibody | UMCh3-IFNa
Mouse anti Chicken Interferon Alpha
- Product Type
- Monoclonal Antibody
- IFN Alpha
|Mouse anti Chicken interferon alpha antibody, clone UMCh3-IFNa recognizes chicken Interferon alpha (chIFN-alpha).
The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken.
There are similarities between chicken IFN and mammalian IFNI with conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes (Staeheli et al. 2001). Chicken IFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that chicken IFN acts as a potent antiviral agent (Marcus et al. 1999).
Mouse anti Chicken interferon alpha antibody, clone UMCh3-IFNa does not cross react with IFN beta or IFN gamma and does not neutralize chIFN-alpha.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Recombinant chicken Interferon alpha.
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
- Western Blotting
- MCA2412 detects a band of approximately 19 kDa.
References for IFN Alpha antibody
Sarmento, L. et al. (2008) Differential host gene expression in cells infected with highly pathogenic H5N1 avian influenza viruses.
Vet Immunol Immunopathol. 125 (3-4): 291-302.
Sick, C. et al. (1996) A family of genes coding for two serologically distinct chicken interferons.
J Biol Chem. 271 (13): 7635-9.
Staeheli, P. et al. (2001) Cytokines of birds: conserved functions--a largely different look.
J Interferon Cytokine Res. 21 (12): 993-1010.
Schwarz, H. et al. (2004) Synthesis of IFN-beta by virus-infected chicken embryo cells demonstrated with specific antisera and a new bioassay.
J Interferon Cytokine Res. 24 (3): 179-84.
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