INI-1 Antibody | 3E10

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INI-1 Antibody | 3E10 gallery image 1

Western blot analysis of INI-1 expression in PC-12 using Mouse anti Human INI-1:Azide Free (MCA3457Z)

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INI-1 Antibody | 3E10 gallery image 2

Staining of paraffin embedded human testis with Mouse anti Human INI-1:Azide Free (MCA3457Z)

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  • INI-1 Antibody | 3E10 thumbnail image 1
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  • Mouse anti Human INI-1:Preservative Free
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  • Product Type
    Monoclonal Antibody
  • Clone
    3E10
  • Isotype
    IgG1
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    MCA3457ZP *, WBdatasheet pdfdatasheet pdf0.1 mg
    MCA3457Z
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    References
    Reviews
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    • Mouse anti Human INI-1 antibody, clone 3E10 recognizes human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, also known as INI-1, BRG1-associated factor 47, BAF47, SMARCB1, Integrase interactor 1 protein or SNF5 homolog. INI-1 is a 385 amino acid ~46 kDa component of the BAF complex involved in chromatin remodelling. INI-1 also acts as a tumor supressor.

      Mutations in the SMARCB1 gene can lead to hereditary cancer syndromes including Rhabdoid tumor predisposition syndrome 1 (RTPS1) with presentation of renal or nervous system tumors or Schwannomatosis 1 (SWNTS1) with development of non-vestibular Schwannomas. Mutation in the SMARCB1 gene can also lead to Mental retardation, autosomal dominant 15 (MRD15) characterised by multiple developmental anomalies, mental retardation and hearing loss (Tsurusaki et al. 2012).
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Western Blotting0.110 ug/ml
      Immunohistology - Paraffin(1)0.110 ug/ml
      (1)
      This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Western Blotting
    • Instructions For Use

    Additional INI-1 Antibody Formats

    Formats Clone Applications Sizes available
    INI-1 Antibody : Preservative Free 3E10 P *, WB 0.1 mg
    • Copyright © 2016 Bio-Rad

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      Recommended Negative Isotype Control

        Useful Reagents

          Recommended Positive Controls

            Histology Controls

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